Czech Brain Aging Study

Czech Brain Aging Study (CBAS) is a longitudinal, observational study on aging and dementia from two large centers in the Czech Republic combining clinical care and clinical research. Our objective is to describe the changes in the cognition over time, brain structure (using MRI), metabolism (cerebro-spinal fluid analysis) and molecular imaging (amyloid PET). Our focus is on those with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and healthy elderly participants - a CBAS cohort. We are also interested in participants with various neurodegenerative dementia syndromes and vascular cognitive impairment (VCI) - a CBAS plus cohort. Our spectrum of diagnoses includes Alzheimer disease, frontotemporal lobar degeneration, dementia with Lewy bodies, Parkinson disease, progressive aphasias, progressive supranuclear palsy, corticobasal degeneration, vascular cognitive impairment and others. The information on participants is entered into CBAS database that contains clinical, laboratory, genetic, socioeconomic and life style variables.