Duke Center for HIV Structural Biology

The Duke Center for HIV Structural Biology (DCHSB) uses high-resolution structures of HIV-1 envelop (Env) glycoproteins to determine a complete, time resolved and atomically detailed mechanism of HIV-1 Env fusion. Define BCR complex structures with specificity of autologous neutralizing antibodies (anAb) and broadly neutralizing antibodies (bnAb) understand the antibody-mediated control of rebound from latent HIV-1 reservoirs at the atomic level. The ultimate goal of these studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the DCHSB will provide resources and training opportunities for early career investigators and trainees who are pursuing careers in the field of HIV-1 structural biology.