EMet Nanotech LLC

Our mission is to make cryo-electron microscopy a reliable and cost effective way to visualize 3D structures in drug design. What is Cryo-Electron Microscopy (Cryo-EM)? ~Biopharma companies use 3D structures of targeted proteins to understand many diseases and develop effective drug therapies ~Cryo-electron microscopy (cryo-EM) has revolutionized the speed and power of protein structure determination, and understanding how proteins interact with drugs ~Critically, in many instances where traditional methods (NMR and X-ray crystallography) fail to create 3D images of complex proteins, cryo-EM has filled this gap Problem: The sample preparation process is dependent on creating a viable sample that the microscope can read which currently depends on trial and error. Our Solution: We have created a technology that requires only our nanofabricated chip to create a thin and consistent sample that can be inserted directly into the current microscopes. Our Technology: ~Materials create capillary forces with hydrophilicity to keep the sample stable and integrated into the chip before frozen ~Design prevents denaturation of protein at the surface of ice layer with no need for large volume or the blotting process ~The chip is created to easily replace current grids but with all the sample prep benefits. Our chip provides faster image processing due to configuration of molecules