Brain pathologies are highly complex disorders. Despite recent progress, their prognosis is grim, defining a high societal challenge. Bridging life sciences, bio-nanotechnology, engineering and ICT, GLADIATOR promises a vanguard and comprehensive theranostic (therapeutic+diagnostic) solution for brain malignancies. Through a multi-faceted breakthrough, GLADIATOR will provide, for the first time, a working prototype of a complete, autonomous and clinically applicable, nanonetwork-based, Molecular Communications system based on the conceptual framework of Externally Controllable Molecular Communications (ECMC). Using Glioblastoma Multiforme tumours, the most detrimental brain pathologies, as a proof-of-concept case, GLADIATOR will implement a platform of cell-based and electronic components. Implantable autologous organoids of engineered neural stem cells (iNSCs) will release rationally designed exosomal bio-nanomachines, delivering reprogramming (therapeutic) miRNAs and building nanonetworks. Interfering with the underlying biological
environment, the nanonetworks will define a revolutionary intervention. A hybrid bio-electronic interface, consisting of coupled external and implantable devices, will enable communication channels with host-derived fluorescent bionanomachines via micro-optoelectronic sensors. The cellular, sub-cellular and electronic components will be integrated into a wireless ECMC network. This system will autonomously monitor the spatiotemporal tumour evolution and recurrence and generate, on demand, appropriate reprogramming interventions, by radiofrequency stimulation of iNSC renewal. A paradigm shift in Oncology Research is anticipated via the supra-discipline of “bio-nanomachine diagnostics”. GLADIATOR establishes a radical long-term vision leading to a drastic change in cancer therapy, also ushering the emergence of the ECMC field and transforming the burgeoning industry of Internet of Nano-bio-things, with high socioeconomic impact.
Company Details
- Founded
- -
- Address
- 1 Panepistimiou Ave, Agladjia,n/a 2109,cyprus
- Industry
- Research Services
- NAICS
-
Scientific Research and Development ServicesResearch and Development in the Physical, Engineering, and Life SciencesResearch and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Website
- http://www.fet-gladiator.edu
- Keywords
- FET Open Project, H2020, Molecular Communications, Externally Controllable Molecular Communications, Glioblastoma, Brain Tumors, theranostics, iNSC, reprogramming, bio-nano-machines.
- HQ
- Agladjia, N/A
Fet Open Gladiator Questions
Fet Open Gladiator's website is http://www.fet-gladiator.edu
Fet Open Gladiator's LinkedIn profile is https://cy.linkedin.com/company/fet-gladiator
Fet Open Gladiator's industry is
Research Services
Fet Open Gladiator's top competitors are
Cpo Scientronics Ltd,
Nipd Genetics,
Kotai Biotechnologies, Inc.,
Revascular Bio,
Algamol,
Renact,
Luxna Biotech Co., Ltd.,
Kiko Tech Co.,ltd,
Geneticist Inc.,
Mirai Innovation Research Institute.
Fet Open Gladiator's categories are Research Services
Fet Open Gladiator's founding year is 2019
