Gradalis is a late-stage clinical biotechnology company developing immunotherapies for multiple cancer indications including an upcoming Phase 3 registration trial in patients with ovarian cancer. The company’s proprietary bi-shRNA therapy platform, which has been proven in its clinical studies, can be utilized to silence a broad range of genes and is applicable to multiple cancer types.
About Vigil
Vigil® is the first cellular therapy to show positive survival benefits in a randomized controlled clinical study of patients with solid tumors. Vigil is a self-navigating cellular immunotherapy that addresses the major deficits of leading cancer treatments. Vigil uses all of a patient’s tumor-related antigens to identify cancer cells and then enhances the training of the immune system to recognize and attack those cells. Gradalis’s proprietary bi-shRNA platform accomplishes this via three key functions: (1) it blocks furin, the enzyme that generates the immunosuppressive cytokines TGF beta types 1 and 2; (2) it activates effector cells including antigen-presenting dendritic cells and CD8+ T cells via the production of GM-CSF; and (3) it induces an immune response to the full complement of neo-antigens from the patient’s tumor via intradermal administration.
In a Phase 2b trial, Vigil showed a positive trend in the primary endpoint of recurrence-free survival in the overall population and a significant improvement in recurrence-free survival and overall survival in a pre-planned subgroup analysis of Stage III/IV newly diagnosed ovarian cancer patients with the BRCA wild type (BRCA-wt) molecular profile. The company is preparing to initiate a clinical study intended for product registration in patients in this subgroup. Additionally, Phase 1 results in an all-comer trial have shown positive signals of activity in multiple tumor types.
Company Details
- Employees
- 25
- Founded
- -
- Address
- 2545 Golden Bear Drive, Suite 110,united States
- Phone
- 214-442-8100
- in****@****inc.com
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- gradalisinc.com
- HQ
- Carrollton, Texas
Gradalis, Inc. Questions
Gradalis, Inc.'s helpline number is 214-442-8100
Gradalis, Inc.'s website is gradalisinc.com
Gradalis, Inc.'s LinkedIn profile is https://www.linkedin.com/company/gradalisinc
Gradalis, Inc. has
25 employees.
View email and phone details for 25
employees at Gradalis, Inc..
Gradalis, Inc.'s industry is
Biotechnology Research
Gradalis, Inc.'s support email address is info@gradalisinc.com
Gradalis, Inc.'s categories are Biotechnology Research
Gradalis, Inc.'s founding year is 2003
