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One-size-fits-(nearly)-all fix for V2R mutations BioWorld MedTech

Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin Nature

Single Drug Could Stabilize Nearly All Mutated Versions of a Human GPCR Genetic Engineering and Biotechnology News

Breakthrough Discovery of a ‘Nearly Universal’ Pharmacological Chaperone for Rare Diseases Bioengineer.org

A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR Nature

Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies ScienceDirect.com

Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Science | AAAS

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy PNAS

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin ScienceDirect.com

Structure of the vasopressin hormone–V2 receptor–β-arrestin1 ternary complex Science | AAAS

Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation PNAS

Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation Nature

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor ScienceDirect.com

Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor PNAS

Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes Nature

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2 Nature

Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors Nature

A cAMP-biosensor-based assay for measuring plasma arginine–vasopressin levels Nature

Functional characterization of a loss-of-function mutant I324M of arginine vasopressin receptor 2 in X-linked nephrogenic diabetes insipidus Nature

Remarkable diversity of vomeronasal type 2 receptor ( OlfC ) genes of basal ray-finned fish and its evolutionary trajectory in jawed vertebrates Nature

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation Nature

Single drug provides first evidence of 'nearly universal' pharmacological chaperone for rare disease Medical Xpress

Enhanced BRET technology for the monitoring of agonist-induced and agonist-independent interactions between GPCRs and β-arrestins Frontiers

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction ScienceDirect.com

Diversity and evolution of the vertebrate chemoreceptor gene repertoire Nature

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease PNAS

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling Frontiers

Pharmacological chaperone approaches for rescuing GPCR mutants: Current state, challenges, and screening strategies ScienceDirect.com

Peptide Agonists of Vasopressin V2 Receptor Reduce Expression of Neuroendocrine Markers and Tumor Growth in Human Lung and Prostate Tumor Cells Frontiers

Jacksonville Transportation Authority Awards Balfour Beatty, Beep and V2R Team Country's Largest-Ever Public Sector Autonomous Shuttle Project PR Newswire

Sensory primary cilium is a responsive cAMP microdomain in renal epithelia Nature

Jacksonville Transportation Authority Announces Groundbreaking of Autonomous Innovation Center (AIC) as Hub for U Business Wire

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling Nature

Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists PNAS

Expression of Nonclassical Class I Major Histocompatibility Genes Defines a Tripartite Organization of the Mouse Vomeronasal System Journal of Neuroscience

​First Look: Colnago V2-r Bicycling

The Winning Bike on Stage 6 of the 2018 Tour de France: Colnago V2-r Bicycling

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK Science | AAAS

"Ballistic" BJ Baldwin Brings the Heat to V2R Off-Road.com

PwC Canada opens applications for V2R Awards with new public sector category BetaKit

Meet your Red Bull Ring Master Red Bull

Sniffing Out the Structure of a Pheromone Receptor-Associated MHC Molecule PLOS

A Joint Vehicle-Vehicle/Vehicle-Roadside Communication Protocol for Highway Traffic Safety Wiley Online Library

Colnago V2-R road bike frameset review Cycling Weekly