Hypha Discovery is a specialist CRO with expertise in scalable synthesis, purification and structure elucidation of metabolites and impurities using biotransformation and late-stage chemical synthesis techniques. We work with pharma and agrochemical companies globally, and also supply metabolite screening and scale-up kits for clients to use in their own labs.
Hypha are also experts in production, purification and structure elucidation of natural products by NMR spectroscopy.
Synthesis of metabolites of drugs and agrochemicals
We create human and other mammalian phase I and phase II metabolites of drug candidates and agrochemicals at mg to gram scale for many pharma and agrochemical companies. Metabolites produced from a variety of phase I reactions are accessible, including both CYP and non-CYP derived mechanisms in addition to conjugated metabolites such as N-, O– & acyl glucuronides and sulfates. We employ a number of techniques in our One-Stop Metabolite Shop to identify the best method for synthesis and scale-up:
• Chemical synthesis
• Recombinant enzymes, including PolyCYPs and PolyUGTs kits
• Microbial biotransformation
• Gut metabolism via human faecal incubations
• Mammalian tissues such as liver fractions (S9/microsomes)
We can provide an end-to-end service including purification, structure elucidation using NMR spectroscopy, and certificates of analysis including qNMR.
Late-stage Oxidation - "PolarExplorer"
Multiple oxidised derivatives of lead compounds can be accessed in parallel from application of the PolyCYPs enzyme platform and our late-stage chemical oxidation platform.
These techniques generate molecules that have increased polarity together with the possibility of greater activity, better selectivity or improved DMPK properties than the parent compound. The process provides an opportunity for expanding chemical space to generate SAR information or to identify derivatives with superior properties.
Company Details
- Employees
- 24
- Founded
- -
- Address
- 154b Brook Drive,, Milton Park,abingdon,oxfordshire Ox14 4sd,united Kingdom
- Phone
- +44 (0)1753 568300
- ma****@****y.co.uk
- Industry
- Research Services
- NAICS
-
Scientific Research and Development ServicesResearch and Development in the Physical, Engineering, and Life SciencesResearch and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Website
- hyphadiscovery.co.uk
- Keywords
- Contract fermentation, Late stage hydroxylation, CYP metabolites, Non-CYP metabolites, Microbial natural products, Small molecule purification, Structure elucidation, Drug metabolites, Environmental fate metabolites, Metabolite kits, Metabolite purification, NMR, Metabolite synthesis, MetID, Glucuronides, Impurity purification and identification.
- HQ
- Milton Park, Abingdon, Oxfordshire
Hypha Discovery Ltd Questions
Hypha Discovery Ltd's helpline number is +44 (0)1753 568300
Hypha Discovery Ltd's website is hyphadiscovery.co.uk
Hypha Discovery Ltd's LinkedIn profile is https://uk.linkedin.com/company/hypha-discovery-ltd
Hypha Discovery Ltd has
24 employees.
View email and phone details for 24
employees at Hypha Discovery Ltd.
Hypha Discovery Ltd's industry is
Research Services
Hypha Discovery Ltd's top competitors are
Galvita Ag,
Evotec,
Axom Solutions,
Sygnature Discovery,
Ludger Limited,
Baxter International Inc.,
Secoya Technologies,
Charnwood Discovery, Part Of Concept Life Sciences,
Eden Research Plc,
Allwater Technologies Ltd.
Hypha Discovery Ltd's support email address is mail@hyphadiscovery.co.uk
Hypha Discovery Ltd's categories are Research Services
Hypha Discovery Ltd's founding year is 2004
