IgG4-TREAT is a Doctoral Network funded by the European Union within the framework of the Marie Skłodowska-Curie Actions (MSCA). The consortium, comprising of 9 host labs and 7 associated partners from 7 EU countries, aims to foster a new generation of experts in IgG4-autoimmune diseases (IgG4-AID) by providing them with a comprehensive training program spanning academic and industry setup. IgG4-TREAT PhD students will pursue 10 individual, multidisciplinary research projects that address the key questions in the IgG4-AID field.
IgG4-AID are rare but collectively correspond to a significant group of devastating diseases affecting many different organs, e.g. skin, brain, nerves and kidney in patients that often remain unresponsive to current treatments. IgG4-AID have commonalities indicating a shared underlying immunopathogenesis that makes a joint approach to identify new therapeutic targets and test new treatment strategies feasible and necessary. We hypothesize that genetic risk factors and a dysregulated immune response may lead to an increased susceptibility to produce antibodies targeting self-proteins. These are of a special subclass called IgG4, which are usually harmless but can cause disease in these patients by interfering with normal functions in the body. We are the first consortium that aims to study IgG4-AID comparatively, including pathogenic IgG4, and the cells, molecules and mechanisms involved in IgG4 autoantibody production, using an explorative multi-omics approach in combination with state-of-the-art cell and molecular biology methodology. We will establish a new humanized mouse model of IgG4-AID for the development and testing of a novel immune-apheresis-based therapy aimed as immediate relief therapy for all IgG4-AID patients.
*Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.
Company Details
- Founded
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- Address
- The Key Questions In The Igg4-Aid Field.
- Industry
- Research Services
- NAICS
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Scientific Research and Development ServicesResearch and Development in the Physical, Engineering, and Life SciencesResearch and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Website
- https://www.igg4-treat.eu
Igg4-Treat Questions
Igg4-Treat's website is https://www.igg4-treat.eu
Igg4-Treat's LinkedIn profile is https://www.linkedin.com/company/igg4-treat
Igg4-Treat's industry is
Research Services
Igg4-Treat's categories are Research Services
Igg4-Treat's founding year is 2023
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