INCIPIT

INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micro-nanostructured Patches for myocardIal regeneraTion The leading cause of death for cardiovascular disease is coronary heart disease. Current therapies do not restore the functionality of damaged myocardial tissue. The only effective therapeutic intervention is an approach able to stimulate the autonomous regeneration of myocardium. The INCIPIT project aims to create a cardiac patch technology with the implementation of electroconductive polymers in order to improve cardiac commitment. The protection against ventricular remodelling and recruitment of stem cells in situ will be pursued through the use of advanced nanotechnologies. The therapeutic product will be validated in vitro using stem and precursor cells, induced pluripotent stem cells, organotypic heart cultures and in vivo using a small animal model. The INCIPIT cardiac patch technology will move this material-based product closer to the market of smart therapies in the cardiovascular field.