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Unveiling the dual role of HIV integrase in viral replication News-Medical

Integrase inhibitors maintain efficacy despite “outside” mutations, UK study finds European AIDS Treatment Group

Host proteins interacting with integrase of human immunodeficiency virus type 1 ScienceDirect.com

Differential effects of switching to integrase strand transfer inhibitors on the gut microbiota and markers of HIV disease progression BMC Microbiology

Analysis of raltegravir analogs to enhance inhibitory efficiency against HIV integrase Nature

New Long-Acting Integrase and Capsid Inhibitor Are on the Horizon POZ - Health, Life and HIV

VH-184 – a new integrase inhibitor CATIE.ca

2024 Acura Integra Type S vs. Modded 1996 Integra SE Car and Driver

Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors ScienceDirect.com

Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study Nature

Site-specific integrase-mediated transgenesis in mice via pronuclear injection PNAS

Structure-Guided Antiviral Peptides Identification Targeting the HIV-1 Integrase ACS Publications

Different Pathways Leading to Integrase Inhibitors Resistance Frontiers

Diabetes mellitus in patients with HIV naïve to antiretroviral therapy initiating integrase inhibitors therapy Nature

View Photos of the 2024 Acura Integra Type S vs. 1996 Acura Integra SE Car and Driver

A mini-review on integrase inhibitors: The cornerstone of next-generation HIV treatment ScienceDirect.com

A phage integrase directs efficient site-specific integration in human cells PNAS

A history-dependent integrase recorder of plant gene expression with single-cell resolution Nature

Variable orthogonality of serine integrase interactions within the ϕC31 family Nature

Genome expansion by a CRISPR trimmer-integrase Nature

Insight into the ERVK Integrase – Propensity for DNA Damage Frontiers

Beware of resistance to 2nd-generation integrase inhibitors: A systematic meta-analysis of HIV-1 integrase inhibitors resistance and drug resistance mutations ScienceDirect.com

Switch to an integrase inhibitor leads to greater weight during and after the menopause Aidsmap

HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro ScienceDirect.com

Retroviral Integrase Structure and DNA Recombination Mechanism ASM Journals

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase PNAS

Structure and function of retroviral integrase Nature

Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase Nature

Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli Nature

Structural basis of second-generation HIV integrase inhibitor action and viral resistance Science | AAAS

Exploring weight changes with different integrase inhibitors CATIE.ca

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration Nature

Effects of different integrase strand transfer inhibitors on body weight in patients with HIV/AIDS: a network meta-analysis BMC Infectious Diseases

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium PNAS

Does changing integrase inhibitors help reduce sleeping problems? CATIE.ca

Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome Nature

Integrase inhibitors do not raise cardiovascular risk in people starting HIV treatment European AIDS Treatment Group

Natural Occurring Polymorphisms in HIV-1 Integrase and RNase H Regulate Viral Release and Autoprocessing ASM Journals

Integrasone Derivatives Isolated from Lepteutypa sp. KT4162 and Their Anti-HIV-1 Integrase Activity ACS Publications

Low level of HIV-1C integrase strand transfer inhibitor resistance mutations among recently diagnosed ART-naive Ethiopians Nature

Identification of an integrase-independent pathway of retrotransposition Science | AAAS

Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium The Lancet

Failure of integrase inhibitor-based regimens may be due to a completely novel form of resistance Aidsmap

Integrase inhibitors raise the risk of diabetes regardless of weight gain Aidsmap

An integrase toolbox to record gene-expression during plant development Nature

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes PNAS

INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication Nature

Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions ACS Publications

A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells Frontiers

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir ASM Journals

A Conformational Switch Controls the DNA Cleavage Activity of λ Integrase ScienceDirect.com

Switches away from integrase inhibitors do not reverse weight gain, studies find Aidsmap

Multivalent interactions essential for lentiviral integrase function Nature

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats Nature

A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes EMBO Press

Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex Nature

Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy Frontiers

Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus Nature

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice PNAS

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors ACS Publications

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions ScienceDirect.com

Clinical class 1 integron-integrase gene – A promising indicator to monitor the abundance and elimination of antibiotic resistance genes in an urban wastewater treatment plant ScienceDirect.com

Identification of an Integrase That Responsible for Precise Integration and Excision of Riemerella anatipestifer Genomic Island Frontiers

Mapping the λ Integrase bridges in the nucleoprotein Holliday junction intermediates of viral integrative and excisive recombination PNAS

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding PNAS

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir PNAS

Development of Murine Leukemia Virus Integrase-Derived Peptides That Bind Brd4 Extra-Terminal Domain as Candidates for Suppression of Acute Myeloid Leukemia ACS Publications

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis ScienceDirect.com

Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions ACS Publications

Comparative architecture of transposase and integrase complexes Nature

Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor ScienceDirect.com

No link between weight gain on integrase inhibitors and diabetes Aidsmap

More evidence that integrase inhibitors don’t raise heart disease risk Aidsmap

Integrase inhibitors more likely to be linked to depression and suicidality than other HIV drugs Aidsmap

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry Nature

Study on suitable analysis method for HIV-1 non-catalytic integrase inhibitor Virology Journal

Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro Frontiers

Real-time observation of CRISPR spacer acquisition by Cas1–Cas2 integrase Nature

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity Nature

Co-occurrence of integrase 1, antibiotic and heavy metal resistance genes in municipal wastewater treatment plants ScienceDirect.com

RAP44 phage integrase-guided 50K genomic island integration in Riemerella anatipestifer Frontiers

Inhibition of HTLV-1 Infection by HIV-1 First- and Second-Generation Integrase Strand Transfer Inhibitors Frontiers

A New Freshwater Cyanosiphovirus Harboring Integrase Frontiers

Efficient targeted transgenesis of large donor DNA into multiple mouse genetic backgrounds using bacteriophage Bxb1 integrase Nature

Gated rotation mechanism of site-specific recombination by ϕC31 integrase PNAS

Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro ScienceDirect.com

Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches Nature

Integrase inhibitor treatment leads to greater weight gain Aidsmap

Developing a Dynamic Pharmacophore Model for HIV-1 Integrase ACS Publications

Development and Application of a Prophage Integrase Typing Scheme for Group B Streptococcus Frontiers

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation Nature

Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor Nature

Integrase-derived peptides together with CD24-targeted lentiviral particles inhibit the growth of CD24 expressing cancer cells Nature

The integrase of genomic island GIsul2 mediates the mobilization of GIsul2 and ISCR-related element CR2-sul2 unit through site-specific recombination Frontiers

Integrase inhibitors do not raise cardiovascular risk in people starting HIV treatment Aidsmap

Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection Nature

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases ACS Publications

Affordable drug resistance genotyping of HIV-1 reverse transcriptase, protease and integrase genes, for resource limited settings BioMed Central

Neural tube defects and integrase inhibitors: still waiting for stronger evidence Aidsmap

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function Nature