IsoChemiX

IsoChemiX: your drug and clinical discovery partner Bespoke Stable Isotope Labelling & Analysis IsoChemiX builds stable isotope-labels into a spectrum of small molecules, oligomers, and protein targets for biopharma and academia. With an analytical suite second to none, IsoChemiX offers complimenting analysis and batch traceability to ensure intact audit trails & documentation. Medicinal Chemistry Focused on Stable Isotopomer Analogs of APIs & Adjuvants IsoChemiX' Medicinal Chemistry function consists of talented and highly qualified scientists who have worked in projects covering complex natural product and multistage drug syntheses. There is considerable drug discovery experience with small molecules and biologicals across a broad range of synthetic and therapeutic areas, e.g. respiratory, inflammation, cancer, metabolic disease, CNS, infection, orphan diseases, and biological drug-target classes, e.g. kinases, GPCRs, ion channels, and antibody-drug conjugates. Core synthetic competencies: Contract synthesis of pro-drugs, full APIs and fragments in labelled heavy and light forms Bespoke heavy and light analog synthesis viz Multi-stage synthesis of complex molecules, both light and heavy analogs - Chiral synthesis, chiral resolutions and chiral HPLC, both preparative and HPLC - Enzyme-mediated chemistry and related enantiomeric resolutions - Synthesis of small peptides and peptide mimetics - Parallel synthesis of lead-seeking arrays or focused libraries - Microwave assisted synthesis - Flow chemistry capability - Ozonolysis capability - Photochemistry capability In due course, integrated clinical discovery projects can be driven by IsoChemix and we aim to design and implement complete in vitro and in vivo screening cascades in combination with established medicinal chemistry expertise.