Klingmüller Lab - Systems Biology of Signal Transduction (DKFZ)

Official account of Ursula Klingmüller's lab at the German Cancer Research Center in Heidelberg. We are focussing on quantitative biology, mathematical models of signaling pathways, systems medicine, and proteomics. Areas of focus in the division are: 1. Advancing systems medicine approaches for clinical translation through standardization of workflows for high-quality data generation and the development of predictive mathematical models 2. Bridging from the single cell to the cell population and organ level to unravel principal mechanisms controlling erythropoietin (Epo)-induced cellular responses in the hematopoietic system. 3. Resolving interactions in the tumor microenvironment determining lung cancer development and personalized optimization of intervention strategies. 4. Deciphering the interconnection of signal transduction and metabolism to unravel mechanisms controlling the compensation of liver injury and to establish model-based biomarkers for early detection of liver cancer. This account is managed by lab members.