Leman Biotech is a clinical-stage cancer immunotherapy company co-founded by Professor Li Tang of the Swiss Federal Institute of Technology in Lausanne (EPFL) and XtalPi, a leader in AI-driven drug research and development. The company integrates innovative metabolic reprogramming technology with a cutting-edge AI drug discovery platform to develop next-generation cancer immunotherapies.
Leman Biotech's Metabolic Reprogramming Technology (Meta 10) represents an innovative approach to combating T-cell exhaustion. Preclinical studies have demonstrated its ability to activate oxidative phosphorylation metabolism in terminally exhausted T cells, restoring their proliferative potential and cytotoxic activity. Promising results from these studies include effective tumor clearance in various mouse models and the induction of stem-like immune memory cells.
In early 2023, Leman Biotech initiated an investigator-initiated clinical trial (IIT) for metabolically armed CD19 CAR-T therapy (Meta10-19 CAR-T) targeting patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) and acute B-lymphoblastic leukemia (r/r B-ALL). Remarkably, all patients treated with Meta10-19 CAR-T have achieved complete responses at low doses with minimal side effects. These findings highlight the immense clinical potential of Meta 10 technology.
The company is headquartered in Shenzhen, a highly vibrant city with the highest number of start-ups per head of population in China, and established a research center in Lausanne Biopôle.
Company Details
- Founded
- 2021
- Address
- Superlab Suisse Lausanne, Route De La Corniche 6,china
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- https://www.lemanbio.com/en/home
- Keywords
- immunotherapy, metabolic, cancer.
- HQ
- Lausanne, Vaud
Leman Biotech Questions
Leman Biotech's website is https://www.lemanbio.com/en/home
Leman Biotech's LinkedIn profile is https://ch.linkedin.com/company/leman-biotech
Leman Biotech's industry is
Biotechnology Research
Leman Biotech's top competitors are
Doppl Sa,
Cellestia Biotech,
Limula,
Sun Bioscience,
Haya Therapeutics,
Newbiologix,
Adc Therapeutics,
Biopôle Lausanne,
Araris Biotech Ag,
Fluosphera.
Leman Biotech's categories are Biotechnology Research
Leman Biotech's founding year is 2021
