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Vitamin D status of adults in the North of the Netherlands: cross-sectional results from the Lifelines cohort study Nature

Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study BMC Genomics

Association of personality facets and cognition in the Lifelines population-based cohort study ScienceDirect.com

Dose-Response and Substitution Analyzes of Sweet Beverage Consumption and Body Weight in Dutch Adults: The Lifelines Cohort Study Frontiers

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study The Lancet

Heritability and the Genetic Correlation of Heart Rate Variability and Blood Pressure in >29 000 Families: American Heart Association Journals

A non-invasive risk score including skin autofluorescence predicts diabetes risk in the general population Nature

Development and internal validation of a prediction model for the presence of tinnitus in a Dutch population-based cohort Frontiers

Educational inequalities in metabolic syndrome prevalence, timing, and duration amongst adults over the life course: a microsimulation analysis based on the lifelines cohort study International Journal of Behavioral Nutrition and Physical Activity

The long-term genetic stability and individual specificity of the human gut microbiome ScienceDirect.com

Skin autofluorescence and cause-specific mortality in a population-based cohort Nature

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes Frontiers

Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals ScienceDirect.com

Assessment of the Dutch Healthy Diet index 2015 in the Lifelines cohort study at baseline Nature

A retrospective study of the MDS criteria for prodromal Parkinson’s disease in the general population Nature

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome Nature

Host genetic regulation of human gut microbial structural variation Nature

Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study | Scientific Reports Nature

Occupational exposures and genetic susceptibility to occupational exposures are related to sickness absence in the Lifelines cohort study Nature

Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study | Translational Psychiatry Nature

Anxiety among healthcare workers during the COVID-19 pandemic: a longitudinal study Frontiers

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses Nature

The mediating role of physical activity and sedentary behavior in the association between working from home and musculoskeletal pain during the COVID-19 pandemic Frontiers

Capturing the fusion of two ancestries and kinship structures in Merovingian Flanders PNAS

Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines Nature

Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population Nature

Global genetic diversity of human gut microbiome species is related to geographic location and host health ScienceDirect.com

Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability Frontiers

Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population ScienceDirect.com

Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes ScienceDirect.com

Using parent‐offspring pairs and trios to estimate indirect genetic effects in education Wiley Online Library

Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes BMC Genomics

Longitudinal analyses of depression and anxiety highlight greater prevalence during COVID-19 lockdowns in the Dutch general population and a continuing increase in suicidal ideation in young adults medRxiv

Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study BioMed Central

Metabolic syndrome in adults with autistic traits: associated psychological, behavioral, and biological factors in females and males – a PharmLines initiative Frontiers

Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile American Heart Association Journals

Differences in lipid and blood pressure measurements between individuals with type 1 diabetes and the general population: a cross-sectional study BMJ Open

The necessity of incorporating non-genetic risk factors into polygenic risk score models | Scientific Reports Nature

Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population ScienceDirect.com

Validation of a clinical and genetic model for predicting severe COVID-19 Cambridge University Press & Assessment

Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population Frontiers

Accurate and Efficient KIR Gene and Haplotype Inference From Genome Sequencing Reads With Novel K-mer Signatures Frontiers

Observational and genetic evidence support a relationship between cardiac autonomic function and blood pressure Frontiers

Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose Nature

The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority Frontiers

Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies BMC Genomics

Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants in MT-CYB, MT-ND4 Genes and Haplogroups Frontiers

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics BMJ Open

The validity and reliability of a digital Ruff Figural Fluency Test (RFFT) BMC Psychology

Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study Nature

Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids Nature

Predictors of new onsets of irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia: the lifelines study Cambridge University Press & Assessment

Newfoundland mom finds healing from postpartum depression in casting lifelines to other 'drowning' mothers struggling to keep up with it all PNI Atlantic News

Loneliness associates strongly with anxiety and depression during the COVID pandemic, especially in men and younger adults Nature

Psychological, behavioural, and physical aspects of caregiver strain in autism-caregivers: a cohort study The Lancet

Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools The Lancet

Effective questionnaire-based prediction models for type 2 diabetes across several ethnicities: a model development and validation study - eClinicalMedicine The Lancet

Languages as Lifelines: The Multilingual Coping Strategies of Refugees from the Early Modern Low Countries Universiteit Leiden

The Genome of the Netherlands: design, and project goals Nature

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels Nature

Tackling health crises with knowledge from Lifelines nwo.nl

Digital Lifelines for Atlantic Canadian Women in Crisis: Rogers Expands Phone Program to Women’s Shelters and Transition Houses Across New Brunswick, Nova Scotia, Prince Edward Island, and Newfoundland and Labrador About Rogers