INSERM U1297 I2MC team LIPSIPLAT (Payrastre & Séverin)

Our laboratory studies phosphoinositide (PI) metabolism in health and diseases. We use integrative and translational approaches to decipher PI signalling and functions in the vascular system (megakaryocytes, platelets and endothelium) and skeletal muscle. We also develop original translational research in the field of cardiovascular diseases in close interaction with clinicians. 𝐏𝐡𝐨𝐬𝐩𝐡𝐨𝐢𝐧𝐨𝐬𝐢𝐭𝐢𝐝𝐞 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 𝐢𝐧 𝐜𝐞𝐥𝐥 𝐟𝐚𝐭𝐞 𝐚𝐧𝐝 𝐝𝐢𝐬𝐞𝐚𝐬𝐞𝐬 Coordinators : Julien VIAUD, Bernard PAYRASTRE Our projects aim to investigate how phosphoinositide signaling regulates important cellular processes such as membrane and cytoskeleton dynamics. We develop bench to bedside strategies to model pathological contexts linked to defects in phosphoinositide metabolism particularly in megakaryocytes, platelets and muscle cells. 𝐏𝐥𝐚𝐭𝐞𝐥𝐞𝐭 𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐢𝐭𝐬 𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐯𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐢𝐧 𝐨𝐫𝐠𝐚𝐧 𝐩𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐩𝐚𝐭𝐡𝐨𝐥𝐨𝐠𝐲 Coordinators : Sonia SEVERIN, Marie-Pierre GRATACAP, Bernard PAYRASTRE Our projects aim to investigate how platelets dialogue with immune cells and with the endothelium to regulate organ functions in normal and pathological contexts. We use cell biology, biochemistry and disease mouse models to investigate the role of platelets in metabolic and cardiovascular diseases and thromboinflammation. 𝐏𝐥𝐚𝐭𝐞𝐥𝐞𝐭 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠 𝐢𝐧 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐚𝐧𝐝 𝐭𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 Coordinators : Bernard PAYRASTRE, Agnès RIBES, Fanny VARDON-BOUNES, Sophie VOISIN Our projects aim to establish translational research in close interaction with the National Reference Center of Platelet Pathologies (CRPP) and clinical departments to investigate the molecular basis of acquired and genetic platelet pathologies. We use bench to bedside approaches to implement diagnostic methods, characterize new platelet pathologies and to improve patient care.