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New mPGES-1 inhibitors disclosed in Nippon Shinyaku patent BioWorld MedTech

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5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates Wiley Online Library

Analgesic effects of a highly selective mPGES-1 inhibitor Nature

Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity Frontiers

mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress American Heart Association Journals

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Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages ScienceDirect.com

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Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53 Nature

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells Frontiers

Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition ScienceDirect.com

A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model Nature

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine Frontiers

Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling ScienceDirect.com

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression Nature

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury Nature

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs Nature

mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1 Nature

DREAM- in -CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1 Nature

Iristectorigenin C suppresses LPS-induced macrophages activation by regulating mPGES-1 expression and p38/JNK pathway ScienceDirect.com

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(9S,13R)-12-oxo-phytodienoic acid attenuates inflammation by inhibiting mPGES-1 and modulating macrophage polarization via NF-κB and Nrf2/HO-1 pathways ScienceDirect.com

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Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor ScienceDirect.com

) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury American Heart Association Journals

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset PNAS

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mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway Nature

Investigating the role of the mPGES-PGE₂-EP4 pathway in Escherichia coli-induced mastitis in dairy cows: insights for non-antibiotic therapeutic strategies Frontiers

Discovery of new potent molecular entities able to inhibit mPGES-1 ScienceDirect.com

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome Frontiers

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IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages British Pharmacological Society | Journals

Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis ScienceDirect.com

Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes ScienceDirect.com

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model Nature

mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival | Pediatric Research Nature

IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages British Pharmacological Society | Journals

synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C ScienceDirect.com

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Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition Frontiers

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Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue Nature

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