Mito Foundation

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The Mito Foundation is the only organisation dedicated to supporting people affected by mitochondrial disease (mito) in Australia. We fund essential research into the prevention, diagnosis, treatment and cures of mitochondrial disorders, and increase awareness and education about this devastating disease. Mito is a debilitating genetic disorder that robs the body’s cells of energy, causing multiple organ dysfunction or failure and potentially death. One Australian baby born each week will develop a severe or life-threatening form of mito. That’s over 50 Australian children each year. Mito is terminal; there are no cures and few effective treatments. We are determined to change this. The Mito Foundation owns and operates The Bloody Long Walk national series, a 35km walking challenge along beautiful scenic routes across Australia. All moneys raised by participants help the Mito Foundation fund research and support for families affected by mito. The Bloody Long Walk offers an opportunity for individuals and businesses to make a meaningful difference to those impacted by the disease while raising awareness in local communities.
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Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine - Science | AAAS

Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine Science | AAAS

Clinical & Experimental Ophthalmology | RANZCO Journal - Wiley Online Library

Clinical & Experimental Ophthalmology | RANZCO Journal Wiley Online Library

Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature

Recommendations for mitochondria transfer and transplantation nomenclature and characterization Nature

Cure Mito Foundation launches resource on Leigh syndrome - EurekAlert!

Cure Mito Foundation launches resource on Leigh syndrome EurekAlert!

Mosaic dysfunction of mitophagy in mitochondrial muscle disease - ScienceDirect.com

Mosaic dysfunction of mitophagy in mitochondrial muscle disease ScienceDirect.com

Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance - Nature

Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance Nature

Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms - Frontiers

Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms Frontiers

Meet the ‘mitomaniacs’ who say mitochondria matter in autism - The Transmitter

Meet the ‘mitomaniacs’ who say mitochondria matter in autism The Transmitter

MitoTox: a comprehensive mitochondrial toxicity database - BMC Bioinformatics

MitoTox: a comprehensive mitochondrial toxicity database BMC Bioinformatics

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo - PNAS

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo PNAS

Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy - American Heart Association Journals

Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy American Heart Association Journals

The challenges of recognising mitochondrial diseases - Medical Republic

The challenges of recognising mitochondrial diseases Medical Republic

Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder - ScienceDirect.com

Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder ScienceDirect.com

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease - Frontiers

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease Frontiers

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF | Circulation Research - American Heart Association Journals

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF | Circulation Research American Heart Association Journals

In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment - PNAS

In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment PNAS

Novel Mito-Nuclear Combinations Facilitate the Global Invasion of a Major Agricultural Crop Pest - Wiley

Novel Mito-Nuclear Combinations Facilitate the Global Invasion of a Major Agricultural Crop Pest Wiley

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency - Nature

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency Nature

NADPH and Mito-Apocynin Treatment Protects Against KA-Induced Excitotoxic Injury Through Autophagy Pathway - Frontiers

NADPH and Mito-Apocynin Treatment Protects Against KA-Induced Excitotoxic Injury Through Autophagy Pathway Frontiers

A defect in mitochondrial protein translation influences mitonuclear communication in the heart - Nature

A defect in mitochondrial protein translation influences mitonuclear communication in the heart Nature

Fast and quantitative mitophagy assessment by flow cytometry using the mito -QC reporter - Frontiers

Fast and quantitative mitophagy assessment by flow cytometry using the mito -QC reporter Frontiers

Nuclear compensatory evolution driven by mito-nuclear incompatibilities - PNAS

Nuclear compensatory evolution driven by mito-nuclear incompatibilities PNAS

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury - Frontiers

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury Frontiers

The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria - Rockefeller University Press

The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria Rockefeller University Press

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis - Frontiers

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis Frontiers

Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases - Frontiers

Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases Frontiers

Mitotherapy for Fatty Liver by Intravenous Administration of Exogenous Mitochondria in Male Mice - Frontiers

Mitotherapy for Fatty Liver by Intravenous Administration of Exogenous Mitochondria in Male Mice Frontiers

Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy | Circulation Research - American Heart Association Journals

Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy | Circulation Research American Heart Association Journals

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis - Journal of Biomedical Science

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis Journal of Biomedical Science

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy - Nature

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy Nature

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy | Circulation Research - American Heart Association Journals

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy | Circulation Research American Heart Association Journals

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature

Mitochondria- and ER-associated actin are required for mitochondrial fusion Nature

Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy | Cell Death & Differentiation - Nature

Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy | Cell Death & Differentiation Nature

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain - PNAS

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain PNAS

Mitochondrial Stress Responses and “Mito-Inflammation” in Cystic Fibrosis - Frontiers

Mitochondrial Stress Responses and “Mito-Inflammation” in Cystic Fibrosis Frontiers

Scientists discover ‘division of labor’ in mitochondria - Science | AAAS

Scientists discover ‘division of labor’ in mitochondria Science | AAAS

Mito‐Bomb: Targeting Mitochondria for Cancer Therapy - Wiley

Mito‐Bomb: Targeting Mitochondria for Cancer Therapy Wiley

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation - PNAS

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation PNAS

SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway - Nature

SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway Nature

Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology - Nature

Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology Nature

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion - EMBO Press

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion EMBO Press

Mitochondrial Dynamics, Mitophagy, and Mitochondria–Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia - Frontiers

Mitochondrial Dynamics, Mitophagy, and Mitochondria–Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia Frontiers

MITOL promotes cell survival by degrading Parkin during mitophagy - EMBO Press

MITOL promotes cell survival by degrading Parkin during mitophagy EMBO Press

A Small‐Molecule Drug for the Self‐Checking of Mitophagy - Gao - 2025 - Angewandte Chemie International Edition - Wiley Online Library

A Small‐Molecule Drug for the Self‐Checking of Mitophagy - Gao - 2025 - Angewandte Chemie International Edition Wiley Online Library

mito -QC illuminates mitophagy and mitochondrial architecture in vivo - Rockefeller University Press

mito -QC illuminates mitophagy and mitochondrial architecture in vivo Rockefeller University Press

MitoNEET is a uniquely folded 2Fe–2S outer mitochondrial membrane protein stabilized by pioglitazone - PNAS

MitoNEET is a uniquely folded 2Fe–2S outer mitochondrial membrane protein stabilized by pioglitazone PNAS

Mitogenomic analysis reveals the phylogenetic placement of monotypic Parachelon grandisquamis and distinctive structural features of control regions in mullets - Frontiers

Mitogenomic analysis reveals the phylogenetic placement of monotypic Parachelon grandisquamis and distinctive structural features of control regions in mullets Frontiers

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage - ACS Publications

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage ACS Publications

Advances in Cardiotoxicity Induced by Altered Mitochondrial Dynamics and Mitophagy - Frontiers

Advances in Cardiotoxicity Induced by Altered Mitochondrial Dynamics and Mitophagy Frontiers

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy - EMBO Press

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy EMBO Press

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy | EMBO reports - EMBO Press

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy | EMBO reports EMBO Press

Miro proteins prime mitochondria for Parkin translocation and mitophagy | The EMBO Journal - EMBO Press

Miro proteins prime mitochondria for Parkin translocation and mitophagy | The EMBO Journal EMBO Press

MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition - ScienceDirect.com

MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition ScienceDirect.com

Global Characterization of Fungal Mitogenomes: New Insights on Genomic Diversity and Dynamism of Coding Genes and Accessory Elements - Frontiers

Global Characterization of Fungal Mitogenomes: New Insights on Genomic Diversity and Dynamism of Coding Genes and Accessory Elements Frontiers

FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases - Frontiers

FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases Frontiers

MitoBlue as a tool to analyze the mitochondria-lysosome communication - Nature

MitoBlue as a tool to analyze the mitochondria-lysosome communication Nature

SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components - Rockefeller University Press

SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components Rockefeller University Press

Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum - Nature

Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum Nature

GAK and PRKCD are positive regulators of PRKN-independent mitophagy - Nature

GAK and PRKCD are positive regulators of PRKN-independent mitophagy Nature

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury - Journal of Neuroscience

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury Journal of Neuroscience

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells - Frontiers

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells Frontiers

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy | EMBO reports - EMBO Press

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy | EMBO reports EMBO Press

Mechanisms and roles of mitophagy in neurodegenerative diseases - Wang - 2019 - CNS Neuroscience & Therapeutics - Wiley Online Library

Mechanisms and roles of mitophagy in neurodegenerative diseases - Wang - 2019 - CNS Neuroscience & Therapeutics Wiley Online Library

Fibre-specific white matter reductions in Alzheimer’s disease and mild cognitive impairment - Oxford Academic

Fibre-specific white matter reductions in Alzheimer’s disease and mild cognitive impairment Oxford Academic

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