NutriEV Project

The NutriEV project explores the pivotal role of extracellular vesicles (EVs) derived from food in nutrition. These nutriEVs are envisioned to serve as superfoods and nutritional biosensors. The project integrates various disciplines, including nutrition, microbiome research, glycan analysis, molecular biology, nanoreagent assembly, biosensors, organoid technologies, in vivo models, and clinical research. NutriEVs obtained from raw and fermented foods are a model for our research. Investigating the glycans associated with NutriEVs will provide insights into how these vesicles may deliver their nutritional cargo to cells. NutriEVs can withstand the digestive process, influencing the gut microbiome and other gut-resident cells, including their secreted EVs. Subsequently, they transcytose across the gut wall into the bloodstream, impacting cellular metabolism and disease. The project delves into the intricate interplay between dietary EVs, the gut residence cell, the microbiome, and their associated EVs. We aim to understand their role in gut health, obesity, and metabolic regulation through a comprehensive array of in vitro, in vivo, and clinical investigations. These EVs are detected in sweat with unique molecular signatures, providing non-invasive biomonitoring technologies to assess nutritional impact. These technologies can potentially revolutionize our ability to evaluate the influence of nutrition. The successful completion of the NutriEV project presents promising translational opportunities for both the food industry and medicine. -- This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101161353.. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or [name of the granting authority]. Neither the European Union nor the granting authority can be held responsible for them --