Pacylex Pharmaceuticals is a clinical stage company developing a first-in-class, daily, oral cancer therapy with a novel, broad, mechanism of action, as a refractory cancer monotherapy and potential future combination therapy. PCLX-001 is a small molecule, N-myristoylation inhibitor that selectively kills cultured human leukemia and lymphoma cells ex-vivo, completely shrinks leukemia and lymphoma tumors in mice including tumors from drug resistant patients, and strongly inhibits growth of solid tumors in mice including breast and certain lung cancers. In an ongoing Phase 1 clinical trial, PCLX-001 has excellent bioavailability, half-life, and drug exposure with an acceptable safety profile to date when administered orally once daily to patients with relapsed advanced solid tumors or refractory B-cell lymphomas. Since this Phase 1 dose escalation clinical study is nearing the target recommended Phase 2 dose (RP2D), Pacylex is planning to expand the clinical program to AML at MD Anderson this fall in a DoD-supported Phase 2 study, as well as start two Phase 2 studies in DLBCL and solid tumor patients.
Company Details
- Employees
- 10
- Founded
- -
- Address
- 10180 101 Street, #2600,canada
- Phone
- 1650-218-1840
- in****@****lex.com
- Industry
- Pharmaceutical Manufacturing
- NAICS
-
Pharmaceutical and Medicine ManufacturingMedicinal and Botanical ManufacturingPharmaceutical Preparation ManufacturingIn-Vitro Diagnostic Substance ManufacturingBiological Product (except Diagnostic) Manufacturing
- Website
- http://www.pacylex.com
- Keywords
- oncology, pharmaceuticals, personalized medicine, chemotherapy, Leukemia, tumors, Lymphoma.
- HQ
- Edmonton, Alberta
Pacylex Pharmaceuticals, Inc. Questions
Pacylex Pharmaceuticals, Inc.'s helpline number is 1650-218-1840
Pacylex Pharmaceuticals, Inc.'s website is http://www.pacylex.com
Pacylex Pharmaceuticals, Inc.'s LinkedIn profile is https://ca.linkedin.com/company/pacylex-pharma
Pacylex Pharmaceuticals, Inc. has
10 employees.
View email and phone details for 10
employees at Pacylex Pharmaceuticals, Inc..
Pacylex Pharmaceuticals, Inc.'s industry is
Pharmaceutical Manufacturing
Pacylex Pharmaceuticals, Inc.'s top competitors are
Panthera Cryosolutions Inc.,
Aurinia Pharmaceuticals Inc.,
Future Fields,
Fedora Pharmaceuticals Inc.,
Syantra Inc.,
Api,
Nanostics Inc.,
Zivo Bioscience, Inc.,
Bioalberta,
Entos Pharmaceuticals.
Pacylex Pharmaceuticals, Inc.'s support email address is info@pacylex.com
Pacylex Pharmaceuticals, Inc.'s categories are Pharmaceutical Manufacturing
Pacylex Pharmaceuticals, Inc.'s founding year is 2012
