Senex is a clinical stage company focused on preventing transcriptional reprogramming, a process by which cancer cells modify gene expression to adapt to adversarial conditions; such adaptation leads to cancer drug resistance and metastasis. Senex’s lead program targets CDK8/19 Mediator Kinase, a protein complex that regulates transcription, but not cell cycle progression. Since CDK8/19 is not essential for adult organisms, its inhibition suppresses drug resistance and metastasis without unwanted side effects. Senex is developing highly selective small-molecule inhibitors of this protein for the treatment of presently incurable types of prostate cancer and breast cancer.
The Company’s lead clinical program, targeting castration resistant prostate cancer (CRPC), is currently supported by a $1.05 million Translational Science Award from the Department of Defense Prostate Cancer Program (DoD PCRP). “The preliminary data are robust and comprehensive in their support and validation of their goal to take SNX631-6 to clinical trials for the treatment of CRPC,” DoD PCRP reviewer.
SNX631-6, the Company’s clinical candidate, is an orally available, selective CDK8/19 inhibitor with nanomolar potency, outstanding selectivity, favorable pharmacokinetics and supratherapeutic toleration in repeat dose range finding studies in murine and primate models. “The preliminary data convincingly indicate the ability of SNX631-6 to inhibit development in CRPC of drug resistance, inhibit growth of bone-resident tumors, inhibit angiogenesis, and suppress expression of tumor-promoting genes in the cancer cells”, DoD PCRP reviewer.
Company Details
- Employees
- 7
- Founded
- -
- Address
- Columbia, Sc
- Phone
- 803-777-6161
- in****@****bio.com
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- senexbio.com
- Keywords
- Providence.
- HQ
- Columbia, SC
Senex Biotechnology. Inc. Questions
Senex Biotechnology. Inc.'s helpline number is 803-777-6161
Senex Biotechnology. Inc.'s website is senexbio.com
Senex Biotechnology. Inc.'s LinkedIn profile is https://www.linkedin.com/company/senex-biotechnology
Senex Biotechnology. Inc. has
7 employees.
View email and phone details for 7
employees at Senex Biotechnology. Inc..
Senex Biotechnology. Inc.'s industry is
Biotechnology Research
Senex Biotechnology. Inc.'s top competitors are
Invocares Foundation,
Vista Clinical Research Group,
Elastrin Therapeutics,
Alexion Pharmaceuticals, Inc.,
J.w. Rew Company,
Aravis Biotech Llc,
Biocentric Health Research,
Perkin Industries,
Viridian Therapeutics, Inc.,
South Carolina Clinical Research Llc..
Senex Biotechnology. Inc.'s support email address is info@senexbio.com
Senex Biotechnology. Inc.'s categories are Biotechnology Research
Senex Biotechnology. Inc.'s founding year is 2002
