Step Pharma

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Step Pharma is the world leader in the discovery and development of inhibitors of CTPS1 (cytidine triphosphate synthase 1) for the treatment of cancer and autoimmune diseases. Step Pharma’s lead program dencatistat (STP938) is a first in class, potent, selective, oral inhibitor of CTPS1 with demonstrated anti-tumor activity. Dencatistat entered clinical development in 2022 in a PhI/II study for the treatment of relapsed and refractory T-cell and B-cell lymphoma. More recently a solid tumour study was started focused on ovarian cancer using the concept of synthetic lethality and biomarker selection of patients. This can ultimately be viewed as a tumour agnostic approach with ovarian cancer being the PoC indication and future plans to expand into other tumour types such as NSCLC with high prevalence of the biomarker.

Company Details

Employees
14
Founded
-
Address
15, Rue Louis Et Auguste Lumière, Saint-Genis-Pouilly,auvergne-Rhône-Alpes 01630,france
Email
in****@****-ph.com
Industry
Biotechnology Research
NAICS
Research and Development in Biotechnology (except Nanobiotechnology)
Keywords
Wilmington.
HQ
Saint-Genis-Pouilly, Auvergne-Rhône-Alpes
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Step Pharma announces the appointment of Dr Karen Smith as Chief Medical Officer - Yahoo Finance

Step Pharma announces the appointment of Dr Karen Smith as Chief Medical Officer Yahoo Finance

Step Pharma to spotlight work in CTPS2-null solid tumours at 2025 EORTC-NCI-AACR International Conference on Molecular Targets and Cancer Therapeutics - The Manila Times

Step Pharma to spotlight work in CTPS2-null solid tumours at 2025 EORTC-NCI-AACR International Conference on Molecular Targets and Cancer Therapeutics The Manila Times

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Advice | Where Ph.D. Programs Fail, Career Coaches Step In - The Chronicle of Higher Education

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Step Pharma announces completion of €38 million Series C financing - The Manila Times

Step Pharma announces completion of €38 million Series C financing The Manila Times

Two-step pH regulating ethanol production through continuous CO/CO - ScienceDirect.com

Two-step pH regulating ethanol production through continuous CO/CO ScienceDirect.com

One-step nanoscale expansion microscopy reveals individual protein shapes - Nature

One-step nanoscale expansion microscopy reveals individual protein shapes Nature

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PH-BN cooperation in Sabah polls rational step – PH Sabah Borneo Post

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Two-step recovery of Pb(II) and Cd(II) with thiophene functionalized hydrogel from lead-acid battery wastewater: Insight into pH-regulated separation - ScienceDirect.com

Two-step recovery of Pb(II) and Cd(II) with thiophene functionalized hydrogel from lead-acid battery wastewater: Insight into pH-regulated separation ScienceDirect.com

One-step fabrication of pH-responsive microcapsules with aqueous cargo using aqueous two-phase system - ScienceDirect.com

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One-step nickel-cobalt alloy electrodeposition from spent lithium-ion battery via synergistic pH adjustment and Mn - ScienceDirect.com

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One-step electrodeposited nickel phosphide electrode for pH-universal electrochemical hydrogen production - ScienceDirect.com

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nanoparticle: Effect of pH in single-step co-precipitation for cancer drug loading - ScienceDirect.com

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One-step laser synthesis platinum nanostructured 3D porous graphene: A flexible dual-functional electrochemical biosensor for glucose and pH detection in human perspiration - ScienceDirect.com

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One-step electrospinning PCL/ph-LPSQ nanofibrous membrane with excellent self-cleaning and oil-water separation performance - ScienceDirect.com

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Co alloy by underwater arc discharge for pH-universal hydrogen evolution reaction - ScienceDirect.com

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AFP: RAA 'significant step' towards advancement of PH, Japan's military ties - Manila Bulletin

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Unraveling the rate-determining step of C2+ products during electrochemical CO reduction | Nature Communications - Nature

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One-Step Preparation of Ph-Sensitive and Antibacterial Calcium Alginate Fibers: In Situ Reduction Method and Original Solution Dyeing - Wiley Online Library

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pHmScarlet is a pH-sensitive red fluorescent protein to monitor exocytosis docking and fusion steps - Nature

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Multi-step nucleation pathway of C-S-H during cement hydration from atomistic simulations - Nature

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Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts - The Lancet

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Mitochondrial dysfunction and oxidative stress in metabolic disorders — A step towards mitochondria based therapeutic strategies - ScienceDirect.com

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A novel approach in revealing mechanisms and particular step predictors of pH dependent tartrazine catalytic degradation in presence of Oxone - ScienceDirect.com

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Unraveling the rate-limiting step of two-electron transfer electrochemical reduction of carbon dioxide - Nature

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Multivalent Protein-Loaded pH-Stable Polymersomes: First Step toward Protein Targeted Therapeutics - Wiley Online Library

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through one-step nitrogen and phosphorus co-doping as an efficient pH-universal electrocatalyst for hydrogen evolution - ScienceDirect.com

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One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation - Nature

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Investigating the presence of adsorbed species on Pt steps at low potentials - Nature

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Ammonia harvesting via membrane gas extraction at moderately alkaline pH: A step toward net-profitable nitrogen recovery from domestic wastewater - ScienceDirect.com

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Green-step assembly of low density lipoprotein/sodium carboxymethyl cellulose nanogels for facile loading and pH-dependent release of doxorubicin - ScienceDirect.com

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Detection of protein concentrations using a pH-step titration method - ScienceDirect.com

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A combined pH and temperature precipitation step facilitates the purification of tobacco-derived recombinant proteins that are sensitive to extremes of either parameter - Wiley Online Library

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-based nanozyme: One step detection of blood glucose at physiological pH - ScienceDirect.com

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Effect of pH on the single-step synthesis of gold nanoparticles using PEO–PPO–PEO triblock copolymers in aqueous media - ScienceDirect.com

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