Structure Based Design, INC.

Structure Based Design, Inc (SBD) provides gene-to-lead integrated drug discovery services and engages in novel drug discovery partnerships. We specialize in protein production, protein structure determination, assay development, structure-based drug design (SBDD), and fragment-based drug design (FBDD) to support lead discovery and optimization. We have worked on over 80 different drug discovery projects and solved hundreds of co-crystal structures for our clients and for internal projects since our inception in 2007. We are conveniently located in San Diego and provided unparalleled scientific support. We have accelerated first-in-class drug discovery efforts using structure-based design approaches, shaving years and millions of dollars off compound development. Drug discovery programs supported by our work have resulted in more than ten clinical stage compounds for our clients. Service Package SBD’s services are milestone based & customer driven. We have flexible service packages that we adapt to meet your research goals. All of our packages include bi-weekly progress updates: Service package I: Crystals & Structures Crystallize target protein provided by client Determine apo-crystal and co-crystal structure Structure analysis, deliver results Service package II: Protein & Co-crystal Structures Design construct, express, purify, and crystallize target. Determine co-crystal structures with one to ten ligands Analyze structures and present results Service package III: High-Throughput Crystal Structures Construct design, large scale protein purification at SBD High throughput co-crystallization. Determine 20-30 co-crystal structures to fully support a client’s drug discovery process. Service Package IV: Early Lead Development Partnership Construct design, large scale protein purification High throughput co-crystallization Determine co-crystal structures to fully support medicinal chemistry and compound optimization. Activity assays, cell-based assays, binding affini