Team 11 : reMoVE-B (CRCI2NA)

Hallmarks of cancer, which include dysregulation of cell cycle, apoptosis and epigenetic remodeling are of tumor and of microenvironment origins. Although these hallmarks favor cancer survival and growth, they also confer specific addictions or vulnerabilities to cancer cells that can be exploited for therapies with regard to cancer heterogeneity and specificity. We work on identifying vulnerabilities that are consequent to the adaptation of cancer cells to survival and resistance within their ecosystem. More precisely, we focus on major molecular mechanisms involved in resistance/escape of cancer cells to death, such as p53 pathway, BCL2 family and epigenetic modifiers networks. We develop original culture models (ex vivo coculture models, PDX) and cutting-edge technologies (Multispectral IHC, multiparameter flow cytometry, scRNASeq). Our research models are mature B-cell malignancies such as Multiple Myeloma and Mantle Cell Lymphoma.