The META Trial

The META Trial* is the largest trial of metformin conducted in Africa. It is aimed at identifying a low-cost intervention to prevent or delay onset of diabetes in individuals living with HIV and pre-diabetes, who are on antiretroviral therapy (ART) in the continent. Not only will it produce globally relevant evidence on this question, but in ancillary studies, we will compare diagnostic methods for diabetes and use various clinical data to describe diabetes and HIV-related complications in this population. Developing clinical skills and capacity for conduct of clinical trials is central to the capacity development aims of the META Trial. *The META Trial is supported by Global Health EDCTP3 and its members. Funded by the European Union under Global Health EDCTP3. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of Global Health EDCTP3 nor its members. Neither of the parties can be held responsible for them.