Thermosome is a clinical-stage drug development company focused on targeted tumor therapy combined with immune stimulation for improved cancer therapy. At its core is a novel, proprietary tumor targeting approach that allows for significantly increased local drug concentrations and improved tumor penetration to achieve improved clinical treatment efficacy.
Thermosome’s lead drug candidate THE001 is a thermosensitive liposomal formulation of the chemotherapeutic drug doxorubicin (DPPG2-TSL-DOX). It has a different mode of action than conventional liposomes. Thermosome's technology enables intravascular drug release initiated by a mild heat trigger using clinically established hyperthermia devices. This results in an up to 15-fold higher local drug concentrations in the tumor and aims to improve clinical treatment efficacy by creating a local boost at the desired site of action. These high local concentrations, which also reach less well perfused areas, aim to overcome drug resistance. This effect cannot be achieved by administration of conventional doxorubicin due to systemic toxicity. Thermosome intends to further enhance treatment efficacy through an additive immune response induced by regional hyperthermia.
The first clinical indication for its lead drug candidate THE001 is soft tissue sarcoma, where the company aims to improve the current standard of care (free doxorubicin). Thermosome´s approach enables targeted tumor treatment independent of specific molecular targets and covers patient populations across all tumor subtypes. THE001 has further development potential in other anthracycline-sensitive solid tumors, such as breast cancer, bladder cancer or ovarian carcinoma.
Company Details
- Employees
- 17
- Founded
- -
- Address
- Am Klopferspitz 19, Planegg,bavaria 82152,germany
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- thermosome.com
- Keywords
- drug development, soft tissue sarcoma, thermosensitive liposome, TSL, orphan disease, oncology, cancer, biotech, tumortargeting, cancertherapy, sarcoma, cancertreatment, clinicaltrial.
- HQ
- Planegg, Bavaria
Thermosome Questions
Thermosome's website is thermosome.com
Thermosome's LinkedIn profile is https://de.linkedin.com/company/thermosome
Thermosome has
17 employees.
View email and phone details for 17
employees at Thermosome.
Thermosome's industry is
Biotechnology Research
Thermosome's categories are Biotechnology Research
Thermosome's founding year is 2015
