Telethon Institute Of Genetics And Medicine (Tigem)

Telethon Institute Of Genetics And Medicine (Tigem) company information, Employees & Contact Information

TIGEM is a leading research institute dedicated to uncovering the molecular mechanisms of rare genetic diseases and translating these discoveries into innovative therapies. As one of Italy’s most prominent centers for biomedical research, TIGEM plays a pivotal role in the international scientific landscape, particularly in the fields of lysosomal storage disorders, membrane trafficking defects, metabolic liver diseases, and inherited eye conditions. Founded and supported by Fondazione Telethon, TIGEM is at the heart of the foundation’s scientific mission to develop new therapeutic approaches for rare genetic disorders. Its unique funding framework empowers researchers to pursue long-term, high-impact projects that are often difficult to support in conventional research environments. Our Mission: 🔬 Advance fundamental, translational, and clinical research that sets new standards of excellence in the field of rare genetic diseases 💊 Accelerate the development of effective therapies, often in partnership with industry, to ensure that scientific breakthroughs reach patients 👩🔬 Train the next generation of scientists and clinicians committed to transforming the future of rare disease treatment Located in a strikingly renovated Olivetti industrial building in Pozzuoli, near Naples, TIGEM’s 5,000 m² campus features modern open-space labs, a large auditorium, and 10 cutting-edge core facilities supporting 26 research groups and over 270 scientists from around the world. TIGEM’s track record includes: 18 European Research Council (ERC) grants 14 EU cooperative research projects coordinated more than 6000 papers published in peer reviewd journals 3 spinoffs around 30 patents TIGEM is more than a research institute—it's a hub of innovation, a talent incubator, and a driver of therapeutic development for some of the world’s most challenging and underserved diseases. 🌐 Learn more: https://www.tigem.it

Company Details

Employees
335
Founded
-
Address
Via Campi Flegrei, 34, Pozzuoli,naples 80078,italy
Industry
Research Services
NAICS
Scientific Research and Development Services
Research and Development in the Physical, Engineering, and Life Sciences
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
Website
tigem.it
Keywords
Pozzuoli.
HQ
Pozzuoli, Naples
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News

New label-free 3D imaging technology offers breakthrough in diagnosing and treating lysosomal storage diseases - EurekAlert!

New label-free 3D imaging technology offers breakthrough in diagnosing and treating lysosomal storage diseases EurekAlert!

FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway - Wiley Online Library

FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway Wiley Online Library

A Further Case Supporting PDCD6IP as the Gene Responsible for a Neurodevelopmental Disorder With Microcephaly - Wiley Online Library

A Further Case Supporting PDCD6IP as the Gene Responsible for a Neurodevelopmental Disorder With Microcephaly Wiley Online Library

C. Thomas Caskey (1938–2022) - Science | AAAS

C. Thomas Caskey (1938–2022) Science | AAAS

Liver‐directed gene therapy for ornithine aminotransferase deficiency - EMBO Press

Liver‐directed gene therapy for ornithine aminotransferase deficiency EMBO Press

Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency - PNAS

Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency PNAS

Out-of-Frame Mutations in ACTN2 Last Exon Cause a Dominant Distal Myopathy With Facial Weakness - Neurology® Journals

Out-of-Frame Mutations in ACTN2 Last Exon Cause a Dominant Distal Myopathy With Facial Weakness Neurology® Journals

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors - PNAS

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors PNAS

Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy - EMBO Press

Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy EMBO Press

Late‐onset mucopolysaccharidosis type IIIA mimicking Usher syndrome - Wiley Online Library

Late‐onset mucopolysaccharidosis type IIIA mimicking Usher syndrome Wiley Online Library

TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression - EMBO Press

TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression EMBO Press

Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis - PNAS

Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis PNAS

Two FAM134B isoforms differentially regulate ER dynamics during myogenesis - EMBO Press

Two FAM134B isoforms differentially regulate ER dynamics during myogenesis EMBO Press

MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma - PNAS

MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma PNAS

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models - EMBO Press

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models EMBO Press

Liver‐directed gene therapy for ornithine aminotransferase deficiency - EMBO Press

Liver‐directed gene therapy for ornithine aminotransferase deficiency EMBO Press

Zinc‐finger‐based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa - EMBO Press

Zinc‐finger‐based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa EMBO Press

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases - EMBO Press

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases EMBO Press

Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A - EMBO Press

Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A EMBO Press

BPS Publications - British Pharmacological Society | Journals

BPS Publications British Pharmacological Society | Journals

Role of trafficking protein particle complex 2 in medaka development - Zappa - 2024 - Traffic - Wiley Online Library

Role of trafficking protein particle complex 2 in medaka development - Zappa - 2024 - Traffic Wiley Online Library

MiT/TFE factors control ER‐phagy via transcriptional regulation of FAM134B | The EMBO Journal - EMBO Press

MiT/TFE factors control ER‐phagy via transcriptional regulation of FAM134B | The EMBO Journal EMBO Press

The awesome lysosome - EMBO Press

The awesome lysosome EMBO Press

Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia - PNAS

Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia PNAS

The impairment of HCCS leads to MLS syndrome by activating a non‐canonical cell death pathway in the brain and eyes - EMBO Press

The impairment of HCCS leads to MLS syndrome by activating a non‐canonical cell death pathway in the brain and eyes EMBO Press

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype - EMBO Press

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype EMBO Press

Nutrient‐sensitive transcription factors TFEB and TFE 3 couple autophagy and metabolism to the peripheral clock - EMBO Press

Nutrient‐sensitive transcription factors TFEB and TFE 3 couple autophagy and metabolism to the peripheral clock EMBO Press

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization - EMBO Press

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO Press

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB - EMBO Press

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB EMBO Press

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors - PNAS

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors PNAS

Daughter‐specific repression of Saccharomyces cerevisiae HO : Ash1 is the commander - EMBO Press

Daughter‐specific repression of Saccharomyces cerevisiae HO : Ash1 is the commander EMBO Press

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