TNC Pharmaceuticals Research Development & Consultancy Ltd

We are an experienced and highly qualified academic and industrial expert group committed to providing timely, high-quality services to local and international pharmaceutical and biotechnology companies. We have four core operational service areas including; o Clinical Pharmacology Services o Bioavailability and Bioequivalence Studies o Regulatory Affairs o Strategic Business Development CLINICAL PHARMACOLOGY SERVICES o Pharmacokinetics (PK) o Pharmacodynamics (PD) o PK/PD interactions and Modeling o Prediction and simulation of human PK o Population pharmacokinetics o Molecular pharmacology o In vitro – in vivo correlation (IVIVC) o Estimating starting dose and dose escalation schemes for first-in-human studies o Design, management, analyze and authoring of; • Phase I-III clinical trials and Comparative clinical bioequivalence trials o Drug development experience across multiple therapeutic modalities including; • Monoclonal antibodies (TNF blocker, C5 blocker, VEGF blocker, PD-1 blocker, HER-2 blocker) • Small molecules (chemotherapeutics, antibiotics, antihypertensives, antidepressants, antidiabetics, analgesics) o Extensive experience in Model-Informed Drug Development (MIDD) o Strong understanding of core concepts and applications in: • Pharmacokinetics (PK), Pharmacokinetics/ Pharmacodynamics (PK/ PD) and Absorption, Distribution, Metabolism and Elimination (ADME) • Population Pharmacokinetics (PK) • Pharmacodynamics (PD), molecular mechanisms of drug action, drug-receptor interactions • Quantitative Systems Pharmacology (QSP) • Proficient with pharmacometric software tools including Phoenix® WinNonlin, NONMEM®, and SAS/STAT®