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STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection ScienceDirect.com

The CSR Mirage: Forced Philanthropy Is No Substitute for Development Moneylife

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia Frontiers

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination Nature

Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM PNAS

Immunohistochemical Analysis of Toll-Like Receptors, MyD88, and TRIF in Human Papillary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma Wiley Online Library

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection | mBio ASM Journals

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways ScienceDirect.com

TRIF-dependent signaling and its role in liver diseases Frontiers

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain PNAS

Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish Nature

TIR Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Participates in Antiviral Immune Responses and Hepatic Lipogenesis of Large Yellow Croaker ( Larimichthys Crocea Frontiers

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88 ScienceDirect.com

E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation PNAS

Cyprinus carpio TRIF Participates in the Innate Immune Response by Inducing NF-κB and IFN Activation and Promoting Apoptosis Frontiers

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection ScienceDirect.com

Beyond MyD88 and TRIF Pathways in Toll-Like Receptor Signaling Frontiers

Heat stress-induced intestinal epithelial cells necroptosis via TLR3-TRIF-RIP3 pathway was dependent on p53 ScienceDirect.com

MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-κB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost Frontiers

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways Frontiers

TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF)-Dependent Antiviral Responses Protect Mice against Ross River Virus Disease | mBio ASM Journals

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway PNAS

TLR3/TRIF pathway confers protection against herpes simplex encephalitis through NK cell activation mediated by a loop of type I IFN and IL-15 from epithelial and dendritic cells Wiley Online Library

Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line ScienceDirect.com

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes Nature

Novel Findings in Teleost TRAF4, a Protein Acts as an Enhancer in TRIF and TRAF6 Mediated Antiviral and Inflammatory Signaling Frontiers

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish Frontiers

Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner Nature

TIR-domain-containing adapter-inducing interferon-β (TRIF) regulates Th17-mediated intestinal immunopathology in colitis Nature

DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS Frontiers

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 Nature

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation PNAS

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases Nature

The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling Nature

Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway Nature

Rapid response team Nature

Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways The Lancet