Vault Pharma’s technology platform uses the human vault particle to deliver peptide payloads for unique immune signaling. We exploit the natural function of the human vault particle which is an immunological signal alert progenitor. Natural vault function is most notably characterized by vault particles being rapidly and robustly ingested by antigen presenting cells, APCs, specifically macrophages and dendritic cells. This favorable and natural property of vaults sets in motion an elegant and robust immune response that is non-inflammatory and results in many propitious effects including stimulation of antigen specific CD4 and CD8 T cells.
Recombinant Vaults Allow for Novel Access To Immune Responses
Recent data in multiple animal and cell models both published and unpublished demonstrate that vaults can and do produce an elegant, sophisticated and highly desired immune response characterized by unusually high and previous undescribed cellular immune responses (both CD4 and CD8) without inflammation, or cytokine storm.
Evidence demonstrates that VPI-101 elicits an enhanced TIL response which recognize and kill cancer. Furthermore, animal studies demonstrate that VPI-101 vaults down regulate the tumor immune suppressive environment; reduced immune suppressive cells (reduce effective response) like T-regulatory cells (Tregs), myeloid derived suppressor cells (MDSC), IL-10 T cells, and induce systemic antitumor responses (stimulating splenic T-cell lytic activity against parental tumor cells).
Recombinant vault particles are safe and non-immunogenic. Human vaults are identical in every person; therefore, they can be delivered as an off-the-shelf therapeutic. Vaults are highly stable, scalable, and homogenous in production
Company Details
- Employees
- 5
- Founded
- -
- Address
- 570 Westwood Plaza,
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- vaultpharma.com
- Keywords
- oncology, infectious disease, nanotechnology.
- HQ
- Los Angeles, CA
Vault Pharma Questions
Vault Pharma's website is vaultpharma.com
Vault Pharma's LinkedIn profile is https://www.linkedin.com/company/vault-pharma
Vault Pharma has
5 employees.
View email and phone details for 5
employees at Vault Pharma.
Vault Pharma's industry is
Biotechnology Research
Vault Pharma's top competitors are
Partillion Bioscience,
Symphony Biosciences,
Rarefied Biosciences,
Magnify Incubator,
Pictorlabs Inc,
Tetrous,
Pelage Pharmaceuticals,
Lucendi, Inc.,
Eximius Diagnostics Corporation,
Port Therapeutics.
Vault Pharma's categories are Biotechnology Research
Vault Pharma's founding year is 2013
