Akari Therapeutics, Plc

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Akari Therapeutics is a biotechnology company developing next-generation precision bi-functional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its innovative ADC discovery platform, the Company has the ability to generate novel bi-functional ADC candidates and optimize them based on the desired application to target a range of cancers to fuel a growing pipeline. Akari’s lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells and with a proprietary linker delivers its novel PH1 payload directly into the tumor. Unlike current ADCs that use tubulin inhibitors and DNA damaging agents as their toxin classes, PH1 is a novel bi-functional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Given this mechanism, AKTX-101 has the potential to overcome many of the shortcomings of current ADCs, off-target toxicity and resistance. In preclinical studies, AKTX-101 has shown to have superior activity, prolonged survival, less resistance and better tolerability and safety. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival in preclinical models. The Company is generating validating data on its novel payloads to advance its pipeline.

Company Details

Employees
13
Address
75-76 Wimpole Street, London,w1g 9rt,united Kingdom
Industry
Biotechnology Research
Website
http://www.akaritx.com
Keywords
Representative jobs.
HQ
London
Competitors
BioXcel Therapeutics, Inc., Tenaya Therapeutics, Biocomposites, Eikon Therapeutics, Lentitek, Nuvation Bio, Peak Bio Inc., Garuda Therapeutics, Callio Therapeutics, Longeveron.
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