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Differentia provides knowledge-empowered modeling and simulation services for effective drug development.
We enable biopharmaceutical companies leveraging our proprietary data, modeling and AI/ML analytics for a deeper understanding of biological systems. Our services accelerate the discovery and delivery of safe and effective therapies to improve healthcare outcomes worldwide.
We provide model-based solutions for all phases of drug development:
Non-Mechanistic Services:
• Preclinical: PK/PD animal models, computing therapeutic indices, and facilitating human translation of preclinical data.
• Phase I: PK/ER models, assessment of random effects, stochastic simulations for FIH dose selection, as well as submission-ready report writing with interpretation.
• Phase II: Population PK/ER model development, covariate analysis, stochastic simulations for RP2D prediction, as well as submission-ready report writing with interpretation.
• Phase III: Non-compartmental analysis (NCA) of Phase II data, develop base models for Population PK analysis, conduct covariate analysis, utilize stochastic simulations or Bayesian predictions to support clinical decision-making, and prepare submission-ready reports.
Mechanistic Services:
• Preclinical: In vitro binding models, PK(Pharmacokinetics)/RO(Receptor Occupancy)/target engagement predictions, and animal/human translational QSP (Quantitative Systems Pharmacology) disease models.
• Phase I: PK/RO/target engagement prediction, Sensitivity Analysis, FIH dose/MTD prediction as well as submission-ready report writing with interpretation.
• Phase II: Efficacious dose/R2PD (Recommended Phase 2 Dose) prediction, sensitivity analysis of parameters, as well as submission-ready report writing with interpretation.
• Phase III: Individual patient PK fitting, Virtual patient cohort development, variability analysis, patient population stratification, biomarker identification, responder/non-responder analysis
Company Details
- Employees
- 7
- Address
- 611 Gateway Blvd,
- Industry
- Biotechnology Research
- Website
- https://differentiabio.com/
- Keywords
- Mechanistic Modeling, Model-informed drug development, PK/PD modeling, PopPK, Noncompartmental analysis, NCA, RP2D prediction, FIH dose selection, QSP, Quantitative Systems Pharmacology, Disease modeling, PK/RO/target engagement prediction, Individual patient PK fitting, Virtual patient cohort development, biomarker identification, patient population stratification.
- HQ
- South San Francisco, California
Differentia Bio Questions
Differentia Bio's website is https://differentiabio.com/
Differentia Bio's LinkedIn profile is https://www.linkedin.com/company/differentiabio
Differentia Bio has
7 employees.
View email and phone details for 7
employees at Differentia Bio.
Differentia Bio's industry is
Biotechnology Research
Differentia Bio's top competitors are
Alivex Biotech,
Access People (Executive Search & Recruitment),
Fes Partners,
Shilo.,
Hudson,
Aboutu Life Sciences,
Strand Life Sciences,
Biomathematica,
Applied Biomath,
Differential Bio.
Differentia Bio's categories are Biotechnology Research
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Top Differentia Bio Employees
-
Atefeh Kazeroonian
Vp Of Mechanistic Modeling At…
Munich, Bavaria, Germany, Germany -
Catherine M Sherwin
Vp Clinical Pharmacology And…
Perth, Western Australia, Australia, Australia2hsc.utah.edu, gmail.com2 +138523XXXXX
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