Differentia provides knowledge-empowered modeling and simulation services for effective drug development.
We enable biopharmaceutical companies leveraging our proprietary data, modeling and AI/ML analytics for a deeper understanding of biological systems. Our services accelerate the discovery and delivery of safe and effective therapies to improve healthcare outcomes worldwide.
We provide model-based solutions for all phases of drug development:
Non-Mechanistic Services:
• Preclinical: PK/PD animal models, computing therapeutic indices, and facilitating human translation of preclinical data.
• Phase I: PK/ER models, assessment of random effects, stochastic simulations for FIH dose selection, as well as submission-ready report writing with interpretation.
• Phase II: Population PK/ER model development, covariate analysis, stochastic simulations for RP2D prediction, as well as submission-ready report writing with interpretation.
• Phase III: Non-compartmental analysis (NCA) of Phase II data, develop base models for Population PK analysis, conduct covariate analysis, utilize stochastic simulations or Bayesian predictions to support clinical decision-making, and prepare submission-ready reports.
Mechanistic Services:
• Preclinical: In vitro binding models, PK(Pharmacokinetics)/RO(Receptor Occupancy)/target engagement predictions, and animal/human translational QSP (Quantitative Systems Pharmacology) disease models.
• Phase I: PK/RO/target engagement prediction, Sensitivity Analysis, FIH dose/MTD prediction as well as submission-ready report writing with interpretation.
• Phase II: Efficacious dose/R2PD (Recommended Phase 2 Dose) prediction, sensitivity analysis of parameters, as well as submission-ready report writing with interpretation.
• Phase III: Individual patient PK fitting, Virtual patient cohort development, variability analysis, patient population stratification, biomarker identification, responder/non-responder analysis
Company Details
- Employees
- 7
- Address
- 611 Gateway Blvd,
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- https://differentiabio.com/
- Keywords
- Mechanistic Modeling, Model-informed drug development, PK/PD modeling, PopPK, Noncompartmental analysis, NCA, RP2D prediction, FIH dose selection, QSP, Quantitative Systems Pharmacology, Disease modeling, PK/RO/target engagement prediction, Individual patient PK fitting, Virtual patient cohort development, biomarker identification, patient population stratification.
- HQ
- South San Francisco, California
Differentia Bio Questions
Differentia Bio's website is https://differentiabio.com/
Differentia Bio's LinkedIn profile is https://www.linkedin.com/company/differentiabio
Differentia Bio has
7 employees.
View email and phone details for 7
employees at Differentia Bio.
Differentia Bio's industry is
Biotechnology Research
Differentia Bio's top competitors are
Shilo.,
Differential Bio,
Alivex Biotech,
Aboutu Life Sciences,
Strand Life Sciences,
Applied Biomath,
Fes Partners,
Hudson,
Access People (Executive Search & Recruitment),
Biomathematica.
Differentia Bio's categories are Biotechnology Research
