IMPORTANT EU Project

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The IMPORTANT project aims to conduct a pragmatic clinical study with a decentralized approach for older patients with refractory advanced HR+/HER2-negative breast cancer, focusing on achieving a high level of evidence (level I) and introducing innovative approaches. The first major innovation is personalized shared decision-making, which tailors the initial dose of CDK 4/6-inhibitors based on each patient's frailty status. This approach combines CDK 4/6-inhibitors and endocrine therapy as an initial treatment strategy, supported by clinical guidelines. Additionally, it implements a mandatory comprehensive geriatric assessment (CGA) and collects patient-reported outcome measures (PROMs) related to quality of life (QoL), potentially leading to the development of a combined geriatric QoL assessment tool. The second innovation focuses on optimizing clinical trial recruitment by facilitating older patients and less tech-savvy individuals to participate in digital healthcare ecosystems. Multidisciplinary collaboration with experts in psychology, user interface/experience (UI/UX) design, and data collection aims to address challenges leading to underrepresentation in clinical studies. The third innovation aims to reduce healthcare costs by developing a financial model to optimize resource utilization. This model addresses the financial burden on healthcare systems, financial toxicity for older patients, and side-effect toxicity. Health Technology Assessment processes will identify correlations to create a valuable financial model for researchers, clinicians, regulators, and policymakers. The fourth critical innovation is the creation of a Geriatric cancer registry. This outcome will contribute to the development of a specialized registry focused on the needs of geriatric patients, not limited to cancer, and advance the state of the art in this field.
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