Inspirna, Inc.

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Inspirna, Inc., is a privately-held clinical-stage biopharmaceutical company focused on the discovery and development of novel cancer drugs that target key pathways in cancers of high unmet need. Inspirna’s lead drug candidate, ompenaclid (RGX-202), is an orally-administered small molecule that targets the CKB/SLC6A8 pathway, which when activated enables the generation of ATP in response to tumor hypoxia. Ompenaclid is currently being tested in multiple mid-stage clinical trials in patients with advanced or metastatic RAS mutant colorectal cancer. Inspirna’s second clinical stage drug candidate, abequolixron (RGX-104), is an oral small molecule activator of LXR/APOE that inhibits angiogenesis and tumor myeloid derived suppressor cells to enhance the immune response against tumors. Abequolixron is currently being tested in a Phase 1b/2 clinical trial in patients with advanced or metastatic lung cancer in combination with docetaxel and endometrial cancer in combination with ipilimumab through a clinical collaboration with Bristol Myers Squibb. Inspirna identifies novel cancer targets using its microRNA-based target discovery platform, RNA-DRIVEr, which was originally developed by Inspirna’s scientific co-founders at The Rockefeller University and exclusively licensed to Inspirna. The Company brings together distinguished scientific founders, a seasoned board of directors, and a leadership team comprised of experienced drug developers.

Company Details

Employees
16
Founded
-
Address
310 E 67th Street,
Industry
Biotechnology
Website
http://www.inspirna.com/
Keywords
Cancer, Drug Discovery, RNA Biology, Ompenaclid (RGX-202), Abequolixron (RGX-104), RNA-DRIVEr.
HQ
New York, NY
Competitors
Vaxart, Inc., Lyndra Therapeutics, CytomX Therapeutics, Empyrean Neuroscience, CARGO Therapeutics, Nkarta, Inc., BioAtla, Inc., Carisma Therapeutics, LifeMine Therapeutics, Arbutus Biopharma Corporation.
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