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Type6 Therapeutics is redefining precision medicine by pioneering a new class of kinase inhibitors that address some of the biggest challenges in targeted drug development: toxicity from poor selectivity, cancer-protective signaling, and acquired resistance.
Rather than jamming disease-driving kinases in their active (ON) state—as most drugs do—Type6’s platform taps into nature’s own regulation system by switching kinases OFF entirely. This OFF-state, while therapeutically powerful, has remained virtually undruggable—until now.
Leveraging breakthroughs in computational biology, multivalent chemistry, and allostery-aware drug design, Type6 has developed a platform that can "staple down" kinases into their OFF configuration. This unlocks access to previously hidden pockets of the human kinome, opening the door to entirely new therapeutic possibilities.
The company’s lead program—a first-in-class CDK2 OFF-state inhibitor—has demonstrated significant advantages over traditional approaches:
100x greater selectivity compared to other CDK2 inhibitors, dual mechanism of action: potent inhibition plus targeted degradation, overcoming common resistance mechanisms, and strong potential in cancers with p53 or MYC alterations, where treatment options are limited.
Backed by a seasoned team of drug discovery veterans and active industry partnerships, Type6 is advancing its CDK2 program while building a pipeline to target additional "undruggable" kinases.
While the long-term vision spans oncology, cardiovascular, neurodegenerative, and autoimmune diseases, Type6’s near-term focus is clear: to unlock the kinome’s hidden therapeutic power in aggressive, late-stage cancers.
Company Details
- Employees
- 5
- Founded
- -
- Address
- Some Of The Biggest Challenges In Targeted Drug Development: Toxicity From Poor Selectivity
- Industry
- Biotechnology Research
- Website
- https://www.type6tx.com/
- Keywords
- Drug Discovery, Drug Development, Oncology, Kinases, CDK2, p53, cMyc, First-in-Class, Drug Resistance, Small Molecules, ADCs, Standalone Therapeutics, Allosteric Inhibition, Selective Target Engagement, Selective Programmed Cancer Cell Death, Breast Cancer, Ovarian Cancer, Colorectal Cancer, Lung Cancer, Scientific Computing.
Type6 Therapeutics Questions
Type6 Therapeutics's website is https://www.type6tx.com/
Type6 Therapeutics's LinkedIn profile is https://www.linkedin.com/company/type6-therapeutics
Type6 Therapeutics has
5 employees.
View email and phone details for 5
employees at Type6 Therapeutics.
Type6 Therapeutics's industry is
Biotechnology Research
Type6 Therapeutics's top competitors are
Pamela Dutton,
Edison Oncology Holding Corp,
Refactor Biosciences,
Bwxt,
Stealth Sf Biotech Startup,
Neurosterix,
Advanced Proteome Therapeutics Incorporated,
Genesis Therapeutics,
Catenabio,
Maia Biotechnology, Inc..
Type6 Therapeutics's categories are Biotechnology Research
Type6 Therapeutics's founding year is 2019
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Top Type6 Therapeutics Employees
-
Gert Kiss
Founding Ceo | Type6 Therapeutics
Nicasio, California, United States, United States2stanford.edu, revolutionmedicines.com1 (781) 2XXXXXXX
-
Jeffrey F. Ohren
Co-Founder And Vp Of Biology For Type6 Therapeutics
West Haven, Connecticut, United States, United States2utoledo.edu, gmail.com
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