Adam Shapiro Email and Phone Number

An extensive record of accomplishments in the pharmaceutical industry as a research biochemist in both big pharma and lean startup environments.Highly experienced in target-based, small-molecule drug discovery, especially for enzyme targets, using multiple modalities, including HTS, fragments, and DEL.Led the team at Entasis Therapeutics investigating potential new project starts.Developed and proposed drug discovery project ideas, identified targets and researched therapeutic indications for a new drug discovery platform in innate immunity; led the multidisciplinary program from its inception to the discovery of potent inhibitors using in-house and external resources; maintained thorough scientific and competitive intelligence knowledge bases; developed and performed biochemical potency and selectivity measurements for all project compounds.Collaborated with CRO and academic lab to test a new project idea, based on literature, measuring hepatotoxicity of endosymbiotic bacterial toxin in liver organoids, with decisive negative result.Business Development team member identifying potential in-licensing opportunities in infectious diseases. Performed due diligence in scientific literature and data rooms. Outsourced experiments to CROs to evaluate compounds.Developed innovative approaches to high-throughout screening-compatible assay formats, especially using fluorescence-based techniques, including FRET and FP. Co-led the team that transferred those assay to the HTS lab for numerous projects.Pioneered techniques for efficient hit evaluation from high-throughout screens that increased efficiency of lead generation by rapidly eliminating false positives and nonspecific inhibitors.Pioneered high-throughput fragment-based lead generation by enzyme assay.Introduced method for correcting assay data for detection interference by compounds that was integrated into the high-throughput screening laboratory workflow and data analysis package.Integrated steady-state enzyme kinetics into biochemical assay design to focus and maximize effectiveness of library screening.Introduced efficient, scientifically rigorous method of measuring potency of time-dependent and covalent inhibitors, facilitating establishment of structure-activity relationships.Post-doctoral research at cancer research institutes demonstrated direct ATP-dependent drug transport by P-glycoprotein and led to the discovery of several features of the multidrug transport mechanism.Ph.D in biochemistry from Cornell University. Investigated the mechanism of chloroplast ATP synthase.