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I am passionate about transforming scientific insights into impactful, actionable strategies that accelerate innovation in CNS therapies. With over 15 years of experience in neuroscience, translational medicine, and strategic consulting, I excel in bridging the gap between basic research and clinical application. As the Founder and Managing Director of The Synaptic Gap, I offer consulting services spanning program and project management, alliance management, business development, and medical science liaison functions.Throughout my career, I've guided multiple drug candidates through Phase II proof-of-concept studies for conditions such as treatment-resistant depression, neuropathic pain, PTSD, neurodegenerative disorders, and age-related cognitive decline. My expertise in program management, strategic alliance building, and intellectual property strategy has helped secure over $6 million in non-dilutive funding, while also developing and implementing clinical and regulatory strategies.I thrive on engaging with cross-functional teams and key opinion leaders (KOLs) to drive scientific and clinical initiatives forward. With a strong foundation in communication, I’ve presented at numerous scientific conferences, published peer-reviewed articles, and cultivated partnerships with stakeholders across clinical and research settings. My experience includes scientific storytelling, developing target product profiles, and tailoring complex data into clear, actionable insights.My skills include program and project management, pipeline development, patent review, clinical study design, and regulatory expertise. If you're interested in collaboration or discussing advancements in CNS therapeutics, feel free to connect!
The Synaptic Gap
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Founder And Managing DirectorThe Synaptic Gap Jun 2023 - PresentAs Founder and Managing Director of The Synaptic Gap, I drive client success through strong relationship-building, comprehensive scientific strategy, and leadership of cross-functional projects that enhance target product profiles and clinical development plans globally. I specialize in developing innovative assays, conducting rigorous preclinical evaluations, and crafting impactful scientific communications. My role includes detailed market analysis and strategic recommendations, as well as in-licensing assessments and regulatory guidance to ensure compliance. Additionally, I support clients with branding—including website design and drafting scientific communications —and in securing substantial non-dilutive funding and venture capital to accelerate their growth.
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Senior Director Of ResearchAptinyx Inc. Sep 2021 - Jun 2023Evanston, Il, UsAs Senior Director of Research at Aptinyx, where I led preclinical and clinical research programs, developed biomarker strategies, and managed cross-functional collaborations to advance our pipeline. My strategic direction in building working models for key therapeutic compounds—such as NYX-458 for cognitive impairment in Parkinson’s disease, NYX-783 for PTSD and substance use disorders, and NYX-2925 for neuropathic pain—demonstrates my ability to set impactful program priorities based on clinical needs and market insights.My leadership extended to managing and mentoring multidisciplinary teams, fostering a culture of scientific rigor, transparency, and collaboration. I oversaw the development and execution of complex research initiatives, securing non-dilutive funding and translating preclinical findings into clinical applications. As head of the cross-functional scientific strategy and communications team, I helped establish a Scientific Advisory Board and crafted high-stakes presentations for stakeholders, including board members, clinicians, investors, and analysts, while ensuring effective communication across departments.I co-authored critical preclinical, non-clinical, and clinical research reports for key regulatory submissions, such as INDs, FDA briefing documents, underscoring my regulatory expertise. Additionally, I collaborated closely with Business Development and Licensing (BD&L) teams, evaluating academic and industry research for potential acquisition and development. My experience balancing complex priorities in dynamic settings uniquely positions me to drive therapeutic pipeline acceleration and effective cross-departmental collaboration. -
Director, ResearchAptinyx Inc. Mar 2021 - Sep 2021Evanston, Il, UsAt Aptinyx, Inc., I led a five-year research alliance with Allergan (later AbbVie) from its inception through successful completion, managing key clinical assets and facilitating critical acquisitions, including rapastinel, apimostinel, and zelquistinel by Allergan. As the primary point of contact for our alliance partners, I oversaw all alliance activities, including joint steering committee (JSC) meetings, working groups, and alliance contractual commitments. My role required strategic relationship-building and seamless collaboration to execute a comprehensive research strategy that advanced both companies' goals.I directly managed Aptinyx’s preclinical research team, engaging with external CROs and academic partners to develop broad projects. I also developed and presented data decks to the JSC, reporting on alliance progress, milestones, and performance metrics. My responsibilities included crafting the portfolio’s scientific strategy, including budget and resource allocation, and balancing alliance priorities with additional Aptinyx programs.Additionally, I worked closely with legal, finance, and commercial teams to maximize the pipeline’s intellectual property value, ensuring alignment across departments to drive strategic outcomes for Aptinyx’s clinical assets.
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Associate Director, Translational ScienceAptinyx Inc. Mar 2018 - Feb 2021Evanston, Il, UsAs Associate Director of Translational Science, I focused on transforming preclinical insights into clinical endpoints that enhanced trial design and improved patient outcomes. Collaborating with preclinical, clinical, and regulatory teams, I developed target product profiles, clinical development plans, and commercialization strategies to maximize the Aptinyx pipeline’s market potential, including targeted efforts for rare diseases and orphan indications.I contributed to key regulatory and SEC filings, co-authoring essential preclinical, non-clinical, and clinical sections for IND submissions, end-of-phase briefings, and an S-1. Additionally, I authored impactful manuscripts and partnered with external stakeholders to broaden the visibility and influence of our research.
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Senior Research ScientistAptinyx Inc. Jul 2016 - Feb 2018Evanston, Il, Us
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Research ScientistAptinyx Inc. Sep 2015 - Jun 2016Evanston, Il, UsI spearheaded a non-dilutive grant funding strategy at Naurex/Aptinyx that secured multiple NIH SBIR/STTR grants. , I also managed all federal reporting for those grants.I managed a team of preclinical research scientists working at Northwestern University, at other academic institutions, and contract research organizations.
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Research ScientistNaurex Inc. May 2013 - Aug 2015Us• demonstrated expertise in the field of molecular neuropharmacology with extensive experience in assay development and validation,• directed non-clinical GLP and non-GLP safety, pharmacology, and toxicology studies for an IND, -
Assistant Research ScientistNaurex Inc. Oct 2011 - Apr 2013UsI have a proven track record of driving innovation, fostering cross-functional collaboration, and delivering results in a dynamic, fast-paced environment while placing the highest importance on collaboration and maintaining personal accountability. I started working with the research laboratory of Dr. Joseph Moskal, PhD at Northwestern University on the development of rapastinel for treatment-resistant depression in 2008 while still a graduate student at the University of New Mexico.
Amanda Barth Skills
Amanda Barth Education Details
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The University Of New MexicoBiology (Neuroscience) -
Austin CollegeBiology
Frequently Asked Questions about Amanda Barth
What company does Amanda Barth work for?
Amanda Barth works for The Synaptic Gap
What is Amanda Barth's role at the current company?
Amanda Barth's current role is Scientific Strategist & Communicator | Expert in Translational Science, Program Management & IP Strategy.
What is Amanda Barth's email address?
Amanda Barth's email address is am****@****nyx.com
What schools did Amanda Barth attend?
Amanda Barth attended The University Of New Mexico, Austin College.
What skills is Amanda Barth known for?
Amanda Barth has skills like Biotechnology, Life Sciences, Molecular Biology, Pharmaceutical Industry, Drug Discovery, Biochemistry, Cell Culture, Science, Data Analysis, Pcr, Cell Biology, Research.
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