Andrea Spencer work email
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Publications:Fleischhacker AS, Sharma A, Choi M, ►Spencer A◄, Bagai I, Hoffman B, and Ragsdale SW. The C-terminal heme regulatory motifs of heme oxygenase-2 are redox-regulated heme binding sites. Biochemistry. 2015 Apr 8. [epub ahead of print]►Spencer AL◄, Bagai I, Becker DF, Zuiderweg ER, and Ragsdale SW. Protein/Protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase. J Biol Chem. 2014 Oct 24;289(43):29836-58.Ragsdale SW, Gupta N, Bagai I, ►Spencer AL◄, and Carter, E., 2013, Thiol/Disulfide redox switches as a regulatory mechanism in heme-binding proteins. in The Handbook of Porphyrin Science (Vol 30), Ferriera, G., ed., in press, World Scientific Publishers.Alegado RA, Grabenstatter JD, Zuzow R, ►Morris A◄, Huang SY, Summons RE, and King N. Algoriphagus machinpongoensis sp. nov. co-isolated with a colonial choanoflagellate. International Journal of Systemic and Evolutionary Microbiology. 2013 Jan;63:163-8.King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, ►Morris A◄, Nichols S, Richter DJ, Salamov A, JGI Sequencing, Bork P, Lim W, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV & Daniel Rokhsar. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 2008 Feb 14;451(7180):783-8.Fitzgerald ML, ►Morris AL◄, Chroni A, Mendez AJ, Zannis VI, Freeman MW. ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux. J Lipid Res. 2004 Feb;45(2):287-94. Fitzgerald ML, ►Morris AL◄, Rhee JS, Anderson LP, Mendez AJ, Freeman MW. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002 Sep 6; 277(36):33178-87.
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ScientistIntegrated Dna Technologies Jul 2021 - Jul 2023Ann Arbor, Michigan, United StatesDeveloped targeted amplicon sequencing panels for Next Generation Sequencing for oncogenes and infectious diseases -
Sr. Research SpecialistMichigan Medicine Aug 2020 - Jun 2021Ann Arbor, Michigan, United StatesI am using genomic and cell biology approaches to understand mechanisms controlling latent HIV infection in hematopoetic stem cells. Latency allows the virus to escape antiviral therapy and prevents a full cure of the disease. -
Research FellowBoston Children'S Hospital/Harvard Medical School Jan 2016 - Aug 2018I am manipulating the transcriptional regulation of megakaryocytes derived from primary human CD34+ and iPS cells to enhance platelet production in vitro.
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Graduate Student Research AssistantUniversity Of Michigan Aug 2006 - Sep 2014• Analyzed the role of protein-protein interactions in the regulation of the heme degradation pathway using in vitro techniques including surface plasmon resonance, nuclear magnetic resonance, chemical crosslinking, and site directed mutagenesis. • Developed assay to examine protein-protein interactions in live cell assays using fluorescence microscopy to observe bifluorescent recombination of target proteins.• Mentored undergraduate student in research project characterizing the role of cysteine residues in biliverdin reductase kinetics and substrate inhibition. -
Research Assistant IiUniversity Of California, Berkeley 2003 - 2005• Probed the evolutionary origin of multicellularity by characterizing proteins in a unicellular protist, the choanoflagellate, that shares a common ancestor with mulicellular organisms. • Developed and characterized antibodies to novel choanoflagellate proteins. • Analyzed biochemical requirements of colony formation for colonial choanoflagellate Proterospongia.
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Research AssistantMassachusetts General Hospital And Harvard Medical School 2001 - 2003• Planned and implemented experiments to characterize functional regions of ATP Binding Cassette Transporter A-1 (ABCA1) using cellular cholesterol efflux assays and co-immunoprecipitations. • Developed new methods to examine cell surface expression of the ABCA1 transporter. • Presented findings at the American Heart Association ATVB meeting poster session.
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Polymerase Chain Reaction (Pcr) TechnicianMillennium Pharmaceuticals 2000 - 2001• Programmed and operated laboratory robotics for the production, analysis, and quality control of high throughput PCR.
Andrea Spencer Skills
Andrea Spencer Education Details
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University Of Michigan, Ann Arbor MiCellular And Molecular Biology -
Environmental Studies
Frequently Asked Questions about Andrea Spencer
What is Andrea Spencer's role at the current company?
Andrea Spencer's current role is Scientist at Integrated DNA Technologies.
What is Andrea Spencer's email address?
Andrea Spencer's email address is as****@****dna.com
What schools did Andrea Spencer attend?
Andrea Spencer attended University Of Michigan, Ann Arbor Mi, Connecticut College.
What skills is Andrea Spencer known for?
Andrea Spencer has skills like Pcr, Cell, Fluorescence Microscopy, In Vitro, Nmr, Site Directed Mutagenesis, Protein Protein Interactions, Research, Surface Plasmon Resonance, Statistics.
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1elonmgmt.com
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Andrea Spencer
Educator/Governance Risk And Compliance/ Business Analyst/Project Management/Strategic Planning/Problem Solver/Developed And Designed A Cyber-Blog Web Application Using Azure’S Cloud Services And Docker.Crandall, Tx -
2aol.com, emeraldhospitality.com
2 +190453XXXXX
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Andrea Spencer
Vice Chair For Research, Pritzker Department Of Psychiatry And Behavioral Health, Ann & Robert H. Lurie Children'S Hospital Of ChicagoBoston, Ma2mghgroup.com, hms.harvard.edu -
Andrea Spencer
Senior Program Manager, Safety Assessment At Charles River LaboratoriesGreenfield, In4yahoo.com, yahoo.com, covance.com, criver.com2 +131776XXXXX
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