Anthony Bozza Email & Phone Number

Worcester, Ma, Us

Massachusetts, United States

• Supported the preparation and submission of the Biologics License Application (BLA) to the FDA for the drug Cendakimab, to ensure regulatory compliance and streamline the transition to large-scale production• Collaborated closely with clinical manufacturing to successfully run 5L satellites and analyze supplemental samples to ensure molecule quality data for a first-in-human clinical campaign• Main contributor to the completion of two mAb clone selection studies including high throughput screening, platform fit evaluation, and short-term stability studies culminating in lead and backup clone presentations to senior management as well as co-authoring multiple clone selection reports• Acted as SME for pCO2 & biomass probe implementation into 5L bioreactors which enabled real-timemonitoring of viable cell densities and CO2 control improving titer output and cell viability• Employed JMP software to formulate DoE's to analyze multiple experimental factors such as temperature shifts, feeding strategy, and gassing conditions. Led the corresponding process development runs from shake flasks through production bioreactors resulting in the co-authorship of a process development report

Massachusetts, United States

Coordinated with the biologics department in set-up, inoculation, sampling, and take-down of 5L bioreactors Specialized in Delta V and Pi Vision software to continuously monitor glucose, DO, and pH levels of 100+ bioreactors while calibrating the according offset values to ensure high cellular proliferation and titer levels Analyzed the resulting data and informed the department of patterns and/or abnormalities present

Worcester, Massachusetts, United States

Geometric Bone Scaffolds• Supported graduate researcher in exploring partial 3D constructs to study the effect of pore geometry on bone regenerative cell behaviors, specifically fibroblast and osteoblast connective tissues• Utilized immunofluorescent staining techniques to analyze cellular behavior quantitative and qualitatively through Keyence imaging and further data analysis Collagen Research Project• Conducted research to explore macromolecular crowders and their effects on Collagen II with the goal of producing an in vitro disease model for cancerous pancreatic tissue cells• Prepared the macromolecular crowder solutions, tested the viscosity using a rheometer, and analyzed the results to determine its viability for future cell culture workMicrofluidic Devices• Assisted in the development of microfluidic devices by utilizing PDMS to control small volumes of liquid• Applied vapor deposition and a sonicator to PDMS to ensure proper plasma bonding to cellular imaging slides for cell culture manipulation and advanced cellular imaging

Worcester, Massachusetts, United States

• Maintained and reproduced the worm strain C. Elegans through mammalian cell culture and the use of a thawing and freezing procedure • Assisted the research lab through general lab maintenance including creating solutions, pouring plates, and autoclaving laboratory materials

Master Of Engineering - Meng, Biomaterials/Tissue Engineering, 3.91

Bachelor Of Science - Bs, Biomedical/Medical Engineering, 3.90