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Oxford-trained physiologist, Stanford Ph.D. in Artificial Intelligence, who has worked for 40+ years at the interface between the biomedical sciences, computation, and information analysis and management. Serial bio-medical and IT entrepreneur: founder, co-founder or founding consultant for a half-dozen startup companies in biomedicine, national security and finance.Skills and experience include:• Medical imaging: advanced visualization, image fusion and image-guided surgery systems.• Data Mining: pattern discovery and recognition in massive and real-time data and text streams.• Information fusion: methods and architectures for integration of information from diverse sources into coherent views of particular domains (“situational awareness”). Fusion of imagery and other scientific and clinical information. Ontological engineering, knowledge graphs and meta-data methodologies that underpin knowledge fusion environments.• Computational systems biology: use of formal domain models and multi-physics, multi-scale simulation technologies for modelling the structure and dynamics of cellular and organ function.• High performance/capability computing: applied to modelling of complex systems and management of very large, complex data repositories and data mining on high-volume, real-time data streams. Development of specialized processors for large-scale scientific computations.• Strategic impact of informatics in biomedicine: impact of data-intensive research on fundamental understanding of biological systems, on drug discovery and development, and on clinical medicine. Advice to senior management of bio-pharmaceutical companies on strategic and technical issues relating to these areas.
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Ceo, FounderProteus AssociatesChipping Campden, Gb -
Ceo, FounderProteus Associates Jan 1985 - PresentOxford, United KingdomProteus Associates is an international consultancy specializing in the applications of artificial intelligence to the life and bio-medical sciences. We have worked on a wide variety of projects in the sector, with clients ranging from start-up companies, to global pharma companies, universities, NGOs and governments. Most of these projects involve the use of AI technologies for knowledge representation, inference, data mining and image analysis at scale. -
Technical Consultant, Product DevelopmentBioprotonics, Inc. Feb 2023 - PresentSanta Barbara, California, United StatesProduct development planning for an innovative magnetic resonance technique for measuring meso-scale tissue characteristics (“textures”) with application to cancer detection. -
Chief Technology AdvisorPametan Feb 2021 - PresentSanta Barbara, Ca, UsaAI applied to IoT systems: development of anomaly detection algorithms based on generative adversarial networks (GANs) for sensor data, and of knowledge graphs (“digital twins”) for causal modelling of built environment systems . -
ConsultantTruedigitalsurgery, Inc. Jan 2019 - PresentSanta Barbara, California, UsaSupport of European clinical trials of an innovative robotic surgical microscope. Consultancy on image fusion for microsurgery, and on use of video analytics/annotation for assessing and improving surgeon behaviours and skills.
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College Advisor In Biomedical SciencesBalliol College, University Of Oxford Oct 2011 - PresentOxford, United KingdomMentoring graduate students in biomedicine. Schools outreach activities. In 2014 I organised and chaired a seminar series on "Privacy Issues in Genomic Medicine," (https://www.oii.ox.ac.uk/events/series/privacy-issues-in-genomic-medicine) funded by the Balliol Interdisciplinary Institute and supported by the Oxford Internet Institute. -
Research AssociateOxford Internet Institute Sep 2007 - PresentWorking on several projects on collaborative infrastructures for life sciences research, on eHealth, and on applications of "big data" analytics to socially and economically important problems, the most recent being a knowledge fusion platform about factors affecting the health of honey bees -- an "internet of things" project. Correlation of online YouTube viewing behaviours and self-declared views related to climate change. -
Technical Advisor, Member Of SabGlobal Health Network Feb 2013 - PresentOxford, United KingdomThe Global Health Network (http://tghn.org), based at the Nuffield Dept. of Medicine, Oxford University, is a "virtual science park" (funded by the Bill and Melinda Gates Foundation and others) for web sites and collaboration networks supporting public health in developing countries. I've advised on their technical infrastructure to support clinical trials and infectious disease surveillance, including data mining of point of care diagnostic data in southern Africa, and mining of Twitter data about HIV and Ebola epidemics to understand how information and misinformation are disseminated. I’m currently working on the idea of using semantic annotations of the network content to improve search accuracy. -
ConsultantTruevision 3D Surgical 2007 - Dec 2018Santa Barbara, California AreaTrueVision produced innovative 3D visualization systems for microsurgery, including image-guided surgery. I was involved in training their surgical customers in ophthalmology and neurosurgery, and also consulting on development of an image fusion application for overlaying CT and MRI pre-operative data onto the live surgical image. TrueVision was sold to Alcon in December 2018. A successor company, TrueDigital Surgery, is currently introducing a new kind of robotic microscope for neurosurgery in collaboration with Aesculap.
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Founding Consultant, Acting CtoCaristo Diagnostics Nov 2017 - Aug 2018OxfordCaristo is a young Oxford start-up which is commercialising a new biomarker for vascular inflammation (and hence heart attack risk) derived from non-invasive imaging. I was involved with seed round funding and a successful InnovateUK grant proposal, with planning the development their IT infrastructure and clinical analysis platform, and also investigated deep learning approaches to image segmentation. Caristo just raised a second round of funding, has received FDA 510k approval, and is expecting a CE Mark for its initial product very soon. -
Co-FounderOxford Data Science Jun 2013 - Apr 2018Oxford, United KingdomOxford Data Science was a new company applying knowledge discovery and network science methods to problems in finance, the environment and healthcare. -
Co-FounderAcademy Of Genomic Medicine Nov 2012 - Dec 2014Sunnyvale, Ca Usa And Oxford, UkThe Academy is a non-profit which aims to produce knowledge-bases and point-of-care tools to help physicians assess the impact of genomic variation on therapy choices, esp. in oncology.
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Member, Sybit Management BoardSystemsx.Ch Apr 2009 - Jun 2011Strategic and technical advice to SyBIT, the information technology platform of SystemsX.ch, the new Swiss National Initiative in Systems Biology
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Chair Of Sab For The Predict ProjectOxford University, Dept. Of Physiology, Anatomy And Genetics 2007 - 2011The preDiCT (www.vph-predict.eu) project, part of the EU-funded "Virtual Physiological Human" (VPH/Physiome) initiative, and led by my old Oxford teacher Prof. Denis Noble, was an ambitious and largely successful attempt to create "top to bottom" computational models of the human heart that can be used to predict the potential cardiac toxicity of drugs. I also developed an exploitation plan for how the work of the project could be effectively transferred into commercial drug development. -
Principal Research Associate, Computational And Systems MedicineUniversity College London Aug 2009 - Apr 2010I was responsible for coordinating some of UCL's "translational medicine" initiatives, in particular with integrating research, preclinical and clinical imaging, and integrating genotypic and clinical information. See www.ucl.ac.uk/csm for more details. -
Co-FounderCloudbroker, Zurich, Switzerland Nov 2008 - Apr 2010CloudBroker is a company which aims to promote the adoption of "cloud computing" (sometimes called "on demand computing" or "software as a service") by helping application developers and users select the right cloud platform for their needs, and helping them to port their applications. -
Co-Founder, Chair Of SabBiowisdom (Now Instem) 2000 - 2008BioWisdom is one of the leaders in scientific knowledge management, and in particular the development of ontology-based knowledge management and analysis systems for drug discovery and development. It was acquired by Instem.
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Consultant, Project Manager SwissbiogridSwiss National Supercomputing Centre (Cscs) Jan 2005 - Jul 2007SwissBioGrid was a successful grass roots project to build a Grid computing infrastructure for life science research in Switzerland. -
ConsultantSwiss Institute Of Bioinformatics 2005 - 2007I helped to develop services of Vital-IT, the SIB's High-performance Computing centre in Lausanne, and to promote their use within the Swiss bio-pharmaceutical industry.
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Co-FounderDynafluidics 2005 - 2006DynaFluidics developed innovative software-controlled microfluidics systems for mixing and separation, with applications to the life sciences.
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Co-FounderGenemark 2003 - 2005GeneMark exploited a new technique for using synthetic DNA sequences for watermarking physical objects such as drug packaging in order to prevent counterfeiting.
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Consultant, Member SabSynomics 1998 - 2000Synomics was a pioneer in the application of CORBA-based middleware to data integration in the life sciences. It was eventually acquired by Accelrys.
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Founding ConsultantParacel, Inc., Pasadena, Ca Jul 1992 - Oct 1998Utra-high performance computers for pattern matching, which were applied to biological sequence analysis and text mining. It was eventually acquired by Celera Genomics.
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Senior ConsultantExperta Intelligent Systems, Zurich, Switzerland 1990 - 1991EIS developed rule-based systems for financial planning and trading.
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Senior EngineerAdac Laboratories 1978 - 1984Sunnyvale, Ca, UsaADAC was a very innovative company where I helped develop some of the earliest digital image processing systems for medicine, including the first commercial digital angiography system, the first all-digital radiotherapy planning system and one of the first picture and archiving communications (PACS) systems. We were involved in the very early days of MRI, and I also worked on the development of an "expert system" for radiological diagnosis. ADAC was eventually acquired by Philips Medical. -
Post-Doctoral FellowUniversity Of Lausanne, School Of Medicine 1977 - 1978I worked on what is now called "connectomics" -- trying to reconstruct the geometry and connectivity of neurons from electron micrographs. It turned out to be too hard then, but is now a burgeoning and very exciting field! I wish I could get involved again.
Arthur Thomas Skills
Arthur Thomas Education Details
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Balliol College, University Of OxfordPhysiology -
Special Graduate Program/Artificial Intelligence -
Neurobiology
Frequently Asked Questions about Arthur Thomas
What company does Arthur Thomas work for?
Arthur Thomas works for Proteus Associates
What is Arthur Thomas's role at the current company?
Arthur Thomas's current role is CEO, founder.
What is Arthur Thomas's email address?
Arthur Thomas's email address is aj****@****tes.com
What is Arthur Thomas's direct phone number?
Arthur Thomas's direct phone number is +177583*****
What schools did Arthur Thomas attend?
Arthur Thomas attended Balliol College, University Of Oxford, Stanford University, University Of Lausanne - Unil.
What skills is Arthur Thomas known for?
Arthur Thomas has skills like Computational Biology, Artificial Intelligence, Data Mining, Life Sciences, Bioinformatics, Machine Learning, Text Mining, Image Processing, High Performance Computing, Drug Discovery, Semantic Web, Genomics.
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Arthur Thomas
Pathology Performance And It Manager At Betsi Cadwaladr University Health BoardGreater Cheshire West And Chester Area -
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