Scientist - Receptor Pharmacology
CurrentGPCR pharmacology with a focus on Neurological disorders.
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Ashley Nilson, Phd is listed as Scientist - Receptor Pharmacology at MapLight Therapeutics, Inc., a with 19 employees, based in San Francisco Bay Area, United States. AeroLeads shows a work email signal at nih.gov and a matched LinkedIn profile for Ashley Nilson, Phd.
Ashley Nilson, Phd previously worked as Postdoctoral Researcher at National Institute Of Neurological Disorders And Stroke (Ninds) and Graduate Research Assistant at The University Of Texas Medical Branch At Galveston. Ashley Nilson, Phd holds Doctor Of Philosophy (Phd), Neuroscience, 3.97 from The University Of Texas Medical Branch At Galveston.
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My career aspirations are to improve people's lives through making better medicines to treat devastating diseases. To do this, I aim to discover novel drugs and develop them into novel treatments. As a molecular pharmacologist, I am well suited for target discovery, validation, and compound optimization during early stage drug development.I have rigorous training in mechanism-of-action studies, structure activity relationships, and working collaboratively to select lead candidates based upon define criteria.I'm a detail oriented and excellent collaborator using in vitro techniques to determine affinity, potency, efficacy, and receptor trafficking that contributed to 7+ significant projects on the dopamine D1 through D5 receptors as well as 5HT2A and orphan receptors. I am well versed in GPCR ligands and current trends including agonist, antagonists, PAMs, NAMs, and functional selectivity.I have the ability to communicate to a wide array of audiences both public and scientific. This has led to multiple awards and invited talks through scientific conferences and in the community. Throughout my career, I continue to engage with family members and the public about science and how I am working to improve health through new medications.Outside of my work, I am always finding new activities to enrich myself including sewing, reading, and baking.
Listed skills include Western Blotting, Immunofluorescence, Cell Culture, Primary Neuron Culture, and 17 others.
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United States
GPCR pharmacology with a focus on Neurological disorders.
Bethesda, Maryland, United States
Pharmacology lead for several SAR projects surrounding the dopamine D1, D2, and D4 receptors. I am working on a variety of ligands including agonists, antagonists, and PAMs. The main goals of these projects are to optimize affinity, function, and metabolic stability to develop lead candidates for therapeutic development.Assays used include competition and saturation radioligand binding assays, functional plate based assays (96 and 384-well formats) including b-arrestin, cAMP, and BRET. I also manage various CROs for compound synthesis, pharmacokinetic and brain penetrance, toxicology, and receptor selectivity.My projects work to advance therapeutic candidates for diseases such as schizophrenia, Parkinson's, and substance use disorders among others. In this role, I have enjoyed my time running experiments and mentoring postbaccalaureate students. In addition, I manage lab inventory and ordering for our entire group.
Galveston
My PhD work focused on the mechanism-of-action of D1 dopamine receptor agonists. Using a variety of D1R selective ligands, I characterized their ability of stimulate cAMP production and recruit beta-arrestin. The results was an array of compounds from distinct pharmacophores, that exhibited varied levels of functional selectivity from G protein biased to no bias. I further demonstrated that the level of beta-arrestin recruitment strongly correlated to receptor endocytosis. This extended the mechanism-of-action of D1R G protein biased agonists (including the new non-catechol ligands) to include reduced endocytosis which may have implications on receptor desensitization and re-sensitization.
Pullman
I worked in a variety of labs ranging from clinical research labs to in vivo drug development. My senior project involved testing the ability of a lead drug candidate for the treatment of Parkinson's disease to penetrate the gastric barrier in addition to the blood brain barrier. I conducted all the motor behavioral testing for three cohorts of rats while being blinded to treatment condition. My results replicated a previous study that used i.p. injections indicating that our compound passes the gastric barrier and could be formulated into a pill in future development.
Other employees you can reach at maplightrx.com. View company contacts for 19 employees →
Ryan Nelson
Colleague at Maplight Therapeutics, Inc.Missoula, Montana, United States
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Gabriel Cisneroz
Colleague at Maplight Therapeutics, Inc.San Francisco Bay Area, United States
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Reyna Palacio
Colleague at Maplight Therapeutics, Inc.Dallas-Fort Worth Metroplex, United States
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Kimberly Thompson
Colleague at Maplight Therapeutics, Inc.San Francisco, California, United States
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Jean Weustenraed
Colleague at Maplight Therapeutics, Inc.Greater Sacramento, United States
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Tessa Van Grack
Colleague at Maplight Therapeutics, Inc.Denver Metropolitan Area, United States
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Jennifer Powell
Colleague at Maplight Therapeutics, Inc.Wilmington, Delaware, United States
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Estefania Reyes Bricio
Colleague at Maplight Therapeutics, Inc.South San Francisco, California, United States
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Madison Quinn
Colleague at Maplight Therapeutics, Inc.Charleston County, South Carolina, United States
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Liliane Leaser
Colleague at Maplight Therapeutics, Inc.Flagstaff, Arizona, United States
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Activities and Societies: Society for Neuroscience Galveston Chapter (past) President: Awarded President's Cabinet Award (grant).
Activities and Societies: Phi Beta KappaConducted research as an undergraduate researcher with Dr. Joseph Harding. I conducted animal.
Quick answers generated from the profile data available on this page.
Ashley Nilson, Phd works for MapLight Therapeutics, Inc..
Ashley Nilson, Phd is listed as Scientist - Receptor Pharmacology at MapLight Therapeutics, Inc..
AeroLeads has found 1 work email signal at @nih.gov for Ashley Nilson, Phd at MapLight Therapeutics, Inc..
Ashley Nilson, Phd is based in San Francisco Bay Area, United States while working with MapLight Therapeutics, Inc..
Ashley Nilson, Phd has worked for Maplight Therapeutics, Inc., National Institute Of Neurological Disorders And Stroke (Ninds), The University Of Texas Medical Branch At Galveston, and Washington State University.
Ashley Nilson, Phd's colleagues at MapLight Therapeutics, Inc. include Ryan Nelson, Gabriel Cisneroz, Reyna Palacio, Kimberly Thompson, and Jean Weustenraed.
You can use AeroLeads to view verified contact signals for Ashley Nilson, Phd at MapLight Therapeutics, Inc., including work email, phone, and LinkedIn data when available.
Ashley Nilson, Phd holds Doctor Of Philosophy (Phd), Neuroscience, 3.97 from The University Of Texas Medical Branch At Galveston.
Ashley Nilson, Phd is listed with skills including Western Blotting, Immunofluorescence, Cell Culture, Primary Neuron Culture, Statistical Data Analysis, Event Planning, Educational Outreach, and Receptor Pharmacology.
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