Audrey Duval Email and Phone Number

Comprendre et contrôler la transmission des bactéries multirésistantes par l'analyse et la modélisation des réseaux d’interactions interindividuelles en milieu hospitalier - Understanding and controlling the spread of multi-resistant bacteria by analyzing and modeling interindividual interactions networks in hospital settings.The purpose of this thesis is to use detailed data on interindividual contact networks, associated with mathematical modelling methods, to study MDR spread in hospitals and improve their control. The first study notably underlined the importance of patient-to-patient contacts in long-term care facilities (LTCF). Moreover, some hospital staff categories, such as hospital porters and physicians, were identified as potential superspreaders based on their contact patterns. In the second part, the impact of the contact network on the spread of two species of Extended-spectrum beta-lactamases (ESBL) Enterobacteriaceae (E. coli and K. pneumoniae) were investigated. This work showed that the contact network was an important driver of ESBL-K. pneumoniae dynamics, but not of ESBLE. coli dynamics over the i-Bird study. The last part of the thesis was dedicated to the development of an agent-based model of MDR spread in hospital settings that explicitly formalizes detailed interindividual contacts. This model allows to assess control measures focused on contact patterns. Using our simations, we evaluated measures associated with hospital staff cohorting and showed it can lead to reduce the MRSA acquisition. This thesis combines network analysis, epidemiology of infectious diseases and dynamic modeling. It allows a better understanding of MDR spread and control in LTCF. Moreover, it brings an innovative tool, intended to bedeveloped, to understand and control BMR spread through contact networks in hospital settings

Stage à l'UMR1181 B2PHIÉvaluation de l'apport du traçage des proximités interindividuelles pour prédire la diffusion d’entérobactéries multi-résistantes

Stage à l'unité VIMAnalyse de la réponse immune induite par un vaccin ciblant les cellules dendritiques XCR1+ de la peau du porc(culture cellulaire (sur PBMC, MDCK, cellules de peau de porcs et ganglions), immunofluorescence, FACS, ELISA, vaccination intradermique sur porcs, dosage protéique, titrage viral, PCR, inactivation virale, microneutralisation, technique de restimulation cellulaire, ...)

Stage unité NOeMIMise en évidence de la survie activité-dépendante des cellules de la muqueuse olfactive chez le rongeurHybridation in situ, immunofluorescence, manipulation sur rats et souris

technicienne au laboratoire d'anatomo-cyto-pathologie