Bas Spaans Email & Phone Number

Oegstgeest, Zh, Nl

Oegstgeest, Zuid-Holland, Nederland

Responsible for LentiViral Vector CMC, including:- Scientific- and Project management- Process- & Analytical Development - CTM manufacturing & supply- Regulatory submissions - Collaborations with CDMO's and External partners

Leiden

Responsible for scientific and project management for Development and Product Life Cycle Management (LCPV) of Parenteral Products (i.e. Vaccines). My responsibilities include:- DS/API process development for Viral vector and RNA based vaccines- Planning, budgeting, cross-functional alignment/coordination, and execution of CMC – Drug Substance (DS)/API deliverables- DS/API Process and plant readiness for various prophylactic and therapeutic vaccine candidates (e.g. COVID19, HIV, RSV and Cancer) - supporting regulatory filings- Implementation of LCPV stage 3, Continued Process Verification (CPV), at Janssen Vaccines sites and external partners- Leading cross-functional and cross-site business improvements initiatives

Leiden, The Netherlands

- Scientific Management and Project Management, including collaborations with CMO’s- Development of sample management strategies - Material Qualifications, Product Improvements, and as a member of a team - Technology Transfer and introduction of new products and processes within JnJ facilities. - Leading cross-functional and cross-site business improvements initiatives

Leiden, The Netherlands

Nov 2016 - Nov 2017| Janssen Supply Chain; Technical operations - Project lead powder medium qualification for the Vaccine Launch Facility - Project lead technical design PACS (perfusion system)Oct 2015 - Oct 2016| Infectious Diseases & Vaccines; Analytical Development; Extraneous agents safety group - Generation of a holistic microbial control strategy for adenovirus-based vaccine manufacturing - Supporting the Subject Matter Expert (SME) microbiology

One of the biggest challenges of 21st century is to efficiently shift from a Fossil-based Economy to a modern competitive Bio-based Economy; an economy in which Biomass, preferably in the form of Agricultural or Food-industrial waste, provides source materials for commodity items such as chemicals, materials or liquid fuels. The project I was involved in contributed to this challenge by the development of a more feasible biological-hydrogen production system using the power of synthetic biology.

Columbus, Ohio Area

Intensive hands-on training in genetic tools for the hyperthermophilic anaerobic Archaeon Thermococcus kodakarensis

International internship at the Joint BioEnergy Institute (JBEI), which is a scientific partnership led by Lawrence Berkeley National Laboratory. I was involved in the development of a new molecular tool for the rapid manipulation of chromosomal elements for strain improvement.

Doctor Of Philosophy (Ph.D.), Molecular Microbiology/Microbial Physiology

Engineering of the hyperthermophilic archaeon Thermocouccus kodakarensis for improved biohydrogen production. Thesis: "Thermococcus.

Master'S Degree, Biotechnology - Cellular/Molecular

with a focus on "Cellular and Molecular Biotechnology" and "Marine Biotechnology" Minor Management and Marketing

Bachelor'S Degree, Biology, Specialization Cellular And Molecular Biology

Education record