Brad De Bruler Email & Phone Number

Developed test methods and SOPs to ensure quality of scientific instrumentation produced. Performed installation and onsite service of Gel Permeation Chromatography (GPC) systems. Trained customers and dealers in the use of GPC and automated Solid Phase Extraction sample prep systems. Provided technical support by phone.Implemented testing procedures for hemoglobin A1c analyzers manufactured on a contract basis at our sister company. Trained technicians on the functional testing of these single purpose ion chromatography systems. Tracked production and parts quality issues. Relayed procedural and technical problems back to our customer. Trained production and test staff on proper execution of documentation.

GMP production of APIs.

Greater San Diego Area

Established LC-MS/MS bioanalytical capabilities and in-vitro ADME assays in support of pre-clinical candidate selection. Provided key data within deadlines to achieve critical corporate milestones. Managed workflow to meet research timelines.

Greater San Diego Area

Set up ADME/Bioanalytical lab instrumentation, and assays. Validated the major in-vitro ADME assays for drug discovery lead optimization and candidate selection. Designed Excel templates and wrote macros for generating standardized LC-MS sample lists and data reduction by assay type.Provided purification and analytical support for Medicinal and Combinatorial Chemistry.

Greater San Diego Area

Performed high throughput LC-MS analysis of targeted libraries in support of purification. Introduced automation and instrumental changes to a long standing experimental protocol. Acted as group liaison to drug discovery project teams. Engaged in efforts to transfer analytical techniques to other company sites. Developed Excel macros for the automated generation of LC-MS sample lists. Evaluated applicability of new instrumentation..

Greater San Diego Area

Performed purification of small molecule compounds by mass triggered LC-MS. Increased sample throughput while decreasing turnaround time. Established guidelines on sample submission for purification. Analyzed combinatorial libraries for purity by LC-MS. Maintained open access analytical LC-MS systems. Trained new users of open access LC-MS systems. Analyzed older libraries for stability problems by LC-MS. Maintained open access Varian NMR, including cryogen filling and minor troubleshooting.

Greater San Diego Area

Bought out by LION Bioscience. See job description at LION.

Greater San Diego Area

Synthesized peptides on solid phase support. Performed purification by large scale HPLC. Prepared reports and cGMP documentation.