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Benjamin Mueller is a Senior Scientist at Photys Therapeutics.
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Senior ScientistPhotys TherapeuticsUnited States
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Senior Scientist, Computational ChemistryPerpetual Medicines Jul 2024 - Present -
Senior ScientistPhotys Therapeutics Jan 2023 - Feb 2024Waltham, Ma, Us• Participated in the development of a novel hetero-bifunctional modality (PHICS) aimed at recruiting kinases for the phosphorylation of protein targets • Developed structure-based methods (SBDD) to determine how hetero-bifunctional molecules engage with kinases and protein targets • Worked on multiple teams, two Drug Discovery programs and three Platform Kinase programs – strategized with medicinal chemists and biologists over direction of projects • Performed global analyses of kinase sequences, structures, phosphorylation propensities to understand strategies for optimal platform targets • Employed a wide variety of software packages including Schrödinger, Desmond, OpenEye, Rosetta, and developed in Python (RDKit, Pandas, SciKit-learn)
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Senior ScientistRoivant Discovery Aug 2021 - Nov 2022Computational Structural Biologist using Rosetta and RDKit to study hetero-bifunctional degrader design
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Postdoctoral ScholarVanderbilt University Sep 2015 - Aug 2021Nashville, Tennessee, UsPostdoctoral Fellow in the laboratory of Prof. Jens Meiler- Worked on the development and application of the biomolecular modeling suite Rosetta- Developed a novel scoring function for evaluating ligand / protein interactions- Sequence and structure analysis of disulfide constrained antibody loops to screen for potential broadly neutralizing antibody targets – with Prof. James Crowe- Computational design of non-canoncial amino acid peptide inhibitors of G protein / SNARE complex formation with Prof. Heidi Hamm- Taught Rosetta semi-annually at a workshop for academia and industry -
Biochemistry Phd CandidateUniversity Of Wisconsin-Madison Aug 2009 - Aug 2015Madison, Wi, UsGraduate student in the laboratory of Prof. Alessandro Senes- Developed de novo prediction program for transmembrane helix dimerization- Computationally determined the geometric constraints for backbone-to-backbone hydrogen bonding in membrane proteins- Used molecular biology techniques to test and refine de novo predictions- Developed more high-throughput workflow for cloning helix gene fragments into E. coli -
Teaching AssistantUniversity Of Wisconsin-Madison 2011 - 2011Madison, Wi, UsSurvey of Bioinformatics TA- Led computer laboratory session teaching students Python- Helped to develop homework assignments and laboratory session plansBiochemistry TA- Led discussion group and helped students one-on-one with questions
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Summer Program For Undergraduate ResearchMedical College Of Wisconsin 2008 - 2008Wi, Us
Benjamin Mueller Education Details
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University Of Wisconsin-MadisonIntegrated Program In Biochemistry -
Valparaiso UniversityBiochemistry
Frequently Asked Questions about Benjamin Mueller
What company does Benjamin Mueller work for?
Benjamin Mueller works for Photys Therapeutics
What is Benjamin Mueller's role at the current company?
Benjamin Mueller's current role is Senior Scientist.
What is Benjamin Mueller's email address?
Benjamin Mueller's email address is be****@****ilt.edu
What is Benjamin Mueller's direct phone number?
Benjamin Mueller's direct phone number is +161593*****
What schools did Benjamin Mueller attend?
Benjamin Mueller attended University Of Wisconsin-Madison, Valparaiso University.
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