Brad Homan Email & Phone Number

Durham, North Carolina, United States

Tarrytown, Ny

Utilized a Quality by Design approach (QbD) to map out design space for single-use Cation Exchange (CEX) membranes. Performed a Design of Experiment (DoE) for bench-scale CEX membrane separations. Collected data and modeled profiles for Host Cell Protein (HCP), Higher-Order Aggregate (HOA), dimer, and yield to determine acceptable operating condition ranges. Evaluated regeneration capability of CEX membranes to assess impurity clearance performance over a cycle lifetime using the operating conditions determined from the DoE. Presented development work for this project to the purification group and suggested future applications of single-use CEX membranes within downstream processing.Exposed to pilot-scale downstream processing, assisting with several pilot-scale harvests and supporting Anion Exchange Chromatography (AEX) and Hydrophobic Interaction Chromatography (HIC) operations. Supported bench-scale polishing chromatography (AEX and HIC) development work with AKTA Avant liquid handling systems and UNICORN software. Assisted with size variant isolation of HMW and LMW species from Drug Substance (DS) using Size Exclusion Chromatography (SEC) to support protein characterization studies that are to be submitted as a part of Biological Licensing Agreements (BLA's). Independently operated bench-scale Tangential Flow Filtration (TFF) systems for enrichment of HMW and LMW species.Exposed to pilot-scale column packing and qualification and independently packed and qualified bench-scale columns with multiple resins. Operated independent pH and conductivity load adjustments to be used for late-stage development work. Additional responsibilities included daily pH and conductivity probe calibration, weekly buffer preparation, and distribution of lab consumables. All development work was recorded on an Electric Lab Notebook (ELN) and consumable use was tracked through a Laboratory Inventory Management System (LIMS).

Cincinnati, Oh

Developed new nitrogen-doping protocols for treating Carbon Nanotubes (CNT) to increase conductivity while maintaining tensile strength. New methods lead to an increased areal loading of active material by 150% and doubled the specific energy storage of the devices. Co-authored an article detailing the findings of the new doping method which was accepted by Carbon journal in 2019, titled "Nitrogen-doped CNT on CNT hybrid fiber as a current collector for high-performance Li-ion capacitors."Utilized Scanning Electron Microscopy (SEM) to observe affects of autoclave time and temperature on CNT fibers and Raman spectroscopy to analyze changes in chemical composition of the fiber. Exposed to methods of Chemical Vapor Deposition (CVD) and its applications within carbon nanotube devices.

Covington, Ky

Oversaw accurate outbound shipment of over 75,000 deliveries per shift and coordinated storage for incoming shipments. Assisted supervisors by training new associates on best workplace practices and safety compliance.

Cincinnati, Oh

Worked independently in a lab performing tests on prototypical filtration systems. Conducted analytical research examining the ability of a bio-char nano-filter to remove heavy ions from sample loads of water. After designing and constructing a piping system, along with creating a P&ID for the system, investigated the ability of a hydrophobic-oleophilic filter to remove increasing concentrations of oil from a sample mixture of oil and water. Additionally assessed the lifetime performance of this filter to determine its sustainability with long-term usage. Compiled data retrieved from these experiments and presented findings to supervisor.

Toledo, Oh

Oversaw kitchen operations by delegating tasks to be completed by kitchen staff and coordinated preparation of food to be served to customers. Ensured the kitchen and all food being prepared surpassed every standard set by the health department. Assisted management during high-traffic business periods by interacting with customers waiting for food and helping the grill staff to ensure food preparation was quick and remained below the expected turnover time.