Brad Snodgrass Email & Phone Number

Cambridge, Massachusetts, Us

Responsible for Bioanalysis and DMPK analysis of in-vitro and in-vivo Pharmacology studies.

Responsible for formulations and QC of oligo-nucleotides used for in-vitro and in-vivo pre-clinical and clinical research studies. Assays include LCMS purity estimations, UV concentration calculations, pH and osmolality tests, as well as LAL Endotoxin assessments. Also contributing to DMPK analytical bioanalysis and QC efforts.

Cambridge, Ma, Us

Conducting LCMS bioanalysis including data reduction, and integration of information into clear reports and oral presentations. Independently developing and employing bioanalytical methods for the quantitative and qualitative analysis of small molecules, metabolites, and biomarkers in various biological matrices. Performing in vitro ADME studies, including metabolic stability, cytochrome P450 inhibition, and plasma protein binding, as necessary. Interacting with multidisciplinary teams to meet project goals and timelines.

Macclesfield, Cheshire, Gb

Managed bioanalysis of client PK and in-vitro ADME studies using LCMS on Waters, Sciex and Agilent platforms. Developed bioanalytical methods, data analysis and interpretation. Performed a broad spectrum of assays including: CYP, UGT & Transporter phenotyping and inhibition/induction DDI; CACO-2, MDCK & PAMPA permeability; reactive metabolite ID and protein binding; automated HTP assays on Tecan platforms. Skilled in IND-enabling report writing and external client communication.

Basel, Baselstadt, Ch

Managed automated HTP microsomal and cell based Metabolic Stability screening of discovery NCE’s using LCMS and Rapid Fire/Q-TOF bioanalysis on Thermo, Sciex and Agilent platforms. Developing and executing novel project specific hypothesis-based clearance assays as well as bioanalytical data analysis and interpretation. Experienced with a broad spectrum of in-vitro ADME assays including: CYP450 & Transporter inhibition DDI; CYP Induction; CACO-2 & PAMPA permeability; HTP Kinetic Solubility on Beckman and Tecan platforms. Currently chair and facilitate monthly cross-platform scientific communication seminars and also skilled in small animal handling and surgeries.

Developed cell-based ADME-TOX products, including fresh and cryo human and animal hepatocytes. Responsible for isolation method and QC assay development, including HPLC and fluorometric based metabolic enzyme activity and induction assays. Manager of ADME-TOX product line manufacturing and supervision of Woburn manufacturing Associates. Products included human and animal tissue fractions, antibodies, Transportocytes and specialty chemicals.

Process development of cell-based transplant therapies. Developed and performed GMP isolations and QC characterizations of human and pig neuronal, hepatocyte, and islet cells for use in human clinical trials.

Boston, Ma, Us

Measured human monocyte and endothelial cytokine responses to in-vivo and in-vitro hemodialysis experiments using radio-immune and ELISA assays.

Biochemistry And Molecular Biology

Bachelor Of Science (Bs), Biology, General