Brian Shin Email & Phone Number

Waltham, Massachusetts, United States

Greater Boston Area

Greater Boston Area

• Tested preclinical samples to support pharmacokinetic evaluation of small molecules and proteins.• Operated a variety of analytical instruments including HPLC-MS, SEC, WCX, SCX, SoloVPE, and Capillary Electrophoresis.• Analyzed and interpreted data; communicated results and presented interpretations at internal meetings.• Planned experiments, organized timelines for assay needs and sample testing, troubleshot when needed, summarized results, wrote and reviewed technical reports.

Cambridge

Identified and resolved analysis related to the formulation and development of clinical protein drug candidates.• Managed protein stability studies for multiple concurrent projects using Capillary Electrophoresis, SEC, CEX, HIAC, MFI, and KF.

Greater Boston Area

-Managed “Open Access” analytical and preparative facilities for the Global Discovery Chemistry group including 6 Waters HPLC-MS systems, 2 Acquity UPLC systems, an Interchim Flash system, and Agilent SEC system.-Facilitated day to day scouting and purification of samples via HPLC cross-functionally with Cardiovascular and Metabolism, Ophthalmology, Oncology, and Early Discovery Chemistry Med-Chem Disease Areas.-Created complex custom methods to meet the needs of other departments. Achiral and Chiral purification support on both semi-prep and preparative scales (milligram to multi-gram scale separations) via HPLC-MS and SFC-MS.

Greater Boston Area

-Spearheaded project to find change in various oncology drugs by developing methodology, organizing team schedules, and analyzing data, resulting in essential findings to continue drug research. -Collaborated with team of 3 in Analytical Department Small Molecules Division to compile and present research findings to senior management and CEO, allowing drug research to advance to next phase of testing.-Designed experimental process for verifying efficacy of Raman instrument by comparing results to FTIR, Karl Fisher and Dissociation Instrument process, creating improved method of testing for entire department. -Partnered with Formulations and R&D divisions to obtain relevant data by trading samples, cross-department training, and sharing research, increasing overall data pool 10%.

Greater Boston Area

-Head Technician under Professor Italiano assisting the study of functions and productions of megakaryocytes.-Delivered timely samples on rigid schedule by extracting fetal livers at 100% success rate, resulting in effective data obtained by senior researchers. Worked extensively with Western Blots and ELISA methods.-Managed entire lab’s supply and schedule by coordinating with 4 Postdoctoral researchers, resulting in smooth operations for 6 months and a variety of successfully published research. Extensive repetition with cGMP.-Presented findings to senior researchers biweekly by consolidating research, synthesizing data, and creating Powerpoint presentations, updating them of the lab's current status.

Greater New York City Area

-Conducted organometallic research with Professor Parkin in a team of 5, delivered key findings, leading to senior researcher published paper.-Tested established ligand with various metals using instruments such as NMR 300/400/500 and the X-ray Diffractometer to identify efficacy of attachment.