Chenghua Yang Email & Phone Number

Shanghai City, China

New York, Ny

• Expertly analyze the pharmacological response of more than 50 different human cancer cell lines to heat shock protein inhibitors and evaluate mechanisms of action.• Identify the anti-tumor efficacy of HSP70 inhibitors on primary human breast cancer tumors ex vivo.• Proficiently developed human xenograft tumor models in immunodeficient mice, dosed mice, as well as collected blood and tissue samples for PK and PD biomarker analysis.

Greater New York City Area

• Created a strategy for the in vitro reconstitution of CBM complex, a key protein complex in NF-κB activation.• Solely characterized the molecular basis for the CBM complex assembly and proficiently illustrated structure-function relationship of the CBM complex.• Progressively led the development of a fluorogenic enzymatic assay for high throughput screen of small molecule inhibitors of MALT1, a key enzyme involved in the pathogenesis of ABC-DLBCL lymphoma.• Initiated the identification and validation of novel small molecule inhibitors of MALT1 by screening ~50,000 compounds on robotic liquid handling platform.• Illustrated the PK/PD and anti-tumor efficacy of novel MALT1 inhibitors in DLBCL mouse xenotransplantation model, as well as in primary human DLBCL tumors.• Expressed various proteins in E. coli and insect cells; purified them by affinity, size exclusion, and ion exchange chromatography.• Worked collaboratively with a multi-disciplinary group of academic researchers and industry colleagues on all related research and laboratory concerns; consequently publishing the results in Cancer Cell.Publication:MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In VivoCancer cell, Volume 22, Issue 6, 11 December 2012, Pages 812–824http://www.sciencedirect.com/science/article/pii/S1535610812004837

Fort Collins, Colorado Area

• Proficiently expressed and purified proteins and DNAs in large scale.• Efficiently determined the interaction between MeCP2 and nucleosomes through biochemical and biophysical methods, which included EMSA, light scattering, limited proteolysis, and analytical ultracentrifugation (AUC).• Developed a strategy for in vitro assembly of nucleosomes with different lengths of DNA.• Identified the structure of MeCP2-nucleosome complexes through small angle X-ray scattering (SAXS); proficiently characterized the structure-function relationship of MeCP2.

• Led the recitation and quiz session in Eukaryotic Cell Biology • Assisted in leading Introductory Genetics Laboratory

Changsha, Hunan China

• Saw patients as a resident pediatrician.• Characterized and documented several rare birth defects.• Tracked 50106 birth defects and assessed the efficacy of their intervention measures.

Ph. D, Biochemistry And Molecular Biology

Activities and Societies: Organized one of the presidential fellow events in Colorado State University.• Predoctoral Fellowship awarded.

M.D. In Clinical Medicine, Clinic Medicine

Awarded Academic Scholarship of Xiangya Medical School.