Christopher Below Email & Phone Number

Schlieren, Zh, Ch

Schlieren, Zurich, Switzerland

• Leadership of the LCMS product development team responsible for the establishmentfor >20 high-quality MS-based biomarker discovery platforms• Development of novel MS-workflows for contract research applications leading to theenhancement of the data quality in real-world contract research studiesacross oncology, immunology and neurosciences areas• Collaboration with external institutions and the operations department to optimize theutility of the BM-discovery pipelines for usage in clinical trails and controlledenvironments (GCP, GLP)• Implementation of matrix-based project- and change-management resulting in >80% ofthe team’s objective and key results (OKR) to significantly exceed the expectations• Representation of Biognosys on the cancer steering committee (CSC) of theFoundation of the national institute of health’s (FNIH) biomarker consortium

Schlieren, Zurich, Switzerland

• Development of LC-MS/MS methods and optimization of multiple novel technologiesleading to the routine identification and quantification of >3000 proteins in humanplasma and >10,000 proteins in human tissues for contract research applications• Establishment of multiple standardized proteomics workflows on > 5 different types ofmass spectrometers including Orbitrap Exploris-480, HF-X, HF & TimsTOF HT• Optimization of the MS-methodologies leading to an increase of the efficiency ofmeasurement by 515%• Creation of >50 automated data analysis pipelines aiming at high-content assessmentof large MS-datasets including correlative studies, differential abundance testing andBM-discovery tools• Presentation of 3 scientific posters and one presentation at multiple scientificconferences including AACR and ASMS

Manchester, Großbritannien

Research Titel: Stiffness-mediated Signalling in the Tumour Microenvironment of Pancreatic CancerLabs of Dr Claus Jorgensen and Prof Dr Martin Humphries • Developed high-quality quantitative LC-MS/MS and HPLC based approaches to analyse highly complex proteome samples including PTM-profiling by applying multiple techniques including S-Trap-, in-gel and in-solution digestion, FASP, high-pH RP fractionation, LFQ, SILAC.• Constructed bioinformatics approaches to operate with big "-omics" datasets using R, Python and machine learning applications to achieve data-driven science.• Derived, established and maintained >25 primary pancreatic cancer organoids lines including patient-derived cultures with high efficiency and optimized those for biochemical assays.• Facilitated outstanding project management and communications skills by directing >20 scientists across five laboratories with a high impact scientific publication to cultivate a transparent and efficiency-driven environment.• Established a highly optimized framework to ensure maximum productivity resulting in authoring/co-authoring of two high-impact manuscripts currently under review/in revision.• Designed and pioneered strategies to achieve highly reproducible solutions for scientific problems leading to two poster Awards at international conferences.

Cambridge, United Kingdom

Lab of Dr Pedro Beltrao• Advanced knowledge of data science and bioinformatics approaches to integrate high-content proteomic (>1200 patients) and genomic (>150 patients) datasets including CPTAC, TCGA and ICGC into analysis workflows.• Boosted data visualization skills in R and python environments using ggplot2, matplotlib, openCV, pheatmap and igraph and established >10 analysis scripts currently implemented in two scientific laboratories.• Handled machine learning solutions for PTM-proteomics datasets to functionally score phosphorylation events.

Senftenberg

Lab of Prof Dr Ursula Anderer• Planned and executed research techniques including RT-qPCR, IF and spheroid formation assays using primary human chondrocytes.• Supported research and development efforts to create new SOPs and advance scientific proposals.• Taught >80 students in cell biology and methods of cell biology by generating a dynamic learning environment to empower various learning styles.

London, Großbritannien

Research Titel: The Investigation of Genomic Instability and its Impact on Drug-Resistance Evolution in Colorectal CancerLab of Dr Marco Gerlinger• Pursued research utilizing single-cell manipulation techniques coupled with NGS approaches on primary patient-derived CRC organoids culminating in winning the best Bachelor thesis award in 2017 at BTU.• Conducted functional drug-resistance evolution studies using genetically modified cancer cell lines in long-term coupled with molecular barcoding approaches to unveil mechanisms and kinetics of genomic instability generation in cancer cells.• Forged a deep understanding of scientific operations and enhanced bioinformatics and data analytics toolkits.

Indianapolis Und Umgebung, Indiana

Research Titel: Dual targeting of APE1/Ref-1 and core signaling pathways of the tumor microenvironment in the KPC mouse model for the development of pancreatic cancer therapeuticsLab of Prof Mark Kelley and Dr Melissa Fishel• Developed drug-screening approaches and workflows necessary for pre-clinical drug development of cancer therapeutics.• Established new SOPs for handling and profiling of 3 specific cancer cell lines for combinatory drug-treatment or siRNA-based knockdown trials.

Doctor Of Philosophy - Phd, Cancer Sciences

• Hosted by research groups of Dr Claus Jorgensen and Prof Martin Humphries. • Tight collaboration with research group of Linda Griffith.

Bachelor Of Science - Bs, Biotechnology, 1,1

Activities and Societies: Member of the Students Parliament; Tutor in Cell Biology and Methods in Cell Biology; Scientific Assistance.

A Level, Biotechnology